血栓弹力图在急性一氧化碳中毒患者中的应用

The application of thrombelastogram in acute carbon monoxide poisoning

目的探讨血栓弹力图(TEG)在急性一氧化碳中毒(ACOP)患者抗凝治疗中的应用价值。方法选取44例确诊为ACOP的患者作为ACOP组,以及45例健康体检者作为对照组,于治疗前后抽取静脉血,做TEG检测及常规凝血试验,并对检测结果进行统计学分析。结果 ACOP患者的TEG主要检测参数,包括反应时间(R)、血栓形成的速度(由α角度反映)、血栓最大幅度(MA),均高于对照组,差异有统计学意义(P<0.01);常规凝血检测的指标,包括凝血酶原时间、活化部分凝血酶原时间、凝血酶时间、纤维蛋白原,两组差异无统计学意义(P>0.01)。结论 TEG指标能更敏感地反映ACOP患者的血小板功能活性,为临床治疗提供一定的参考。

Objective To discuss the method and values of thrombelastogram（TEG） in the patients with acute carbon monoxide poisoning（ACOP） who are anticoagulant therapy. Methods 44 patients with ACOP and 45 health physical examination were en rolled in the study as ACOP group and control group respectively. Before and after treatment, blood samples were collected and were tested by using TEG and routine haemostatic assays. Then the results of these tests were analyzed statistically. Results In the pa tients with ACOP, the study showed that major parameters of thrombelastograph, Including response time（R）, coagulation rate（a）, and maximal amplitude of thrombus （MA） significantly increase （P〈0.01）, while TT, APTT, PT, FIB showed no significant differ ence compared to control group（P〉0.01）. Conclusion TEG indexes can reflect the function of platelet in patients with ACOP more sensitively,and provide a reference for clinical treatment.