摘要
目的探讨p53、Bcl-2蛋白表达与食管鳞癌的发生发展及放化疗疗效的关系。方法用免疫组织化学法测定50例食管鳞癌患者放化疗前活检组织中p53与Bcl-2蛋白表达,观察指标表达阳性率以及与临床病理特征的关系及与放化疗疗效的相关性。结果p53、Bcl-2蛋白在食管鳞癌组织表达阳性率(42%和68%)与正常组织表达阳性率(12%和10%)之间差异有统计学意义(P<0.05);Bcl-2蛋白表达与食管鳞癌的分化程度相关(P<0.05),p53蛋白表达与淋巴结转移相关(P<0.05);p53蛋白阴性表达组放化疗疗效优于阳性表达组(P<0.05),Bcl-2蛋白表达与食管鳞癌的疗效无关(P>0.05)。结论p53、Bcl-2蛋白表达与食管鳞癌的发生发展有关,p53蛋白检测可作为食管鳞癌患者放化疗敏感性的判断指标。
Objective To explore the protein expressions of p53, Bcl-2 in esophageal squamous cancer and their relationship with chemoradiotherapy efficacy. Methods The protein expressions of p53 and Bcl-2 in biopsy tissue of 50 cases of patients with esophageal squamous cancer before chemoradiotherapy were measured,the relationships between p53 and Bcl-2 positive rate and clinicalpathologic characteristics and chemoradiotherapy efficacy were analyzed. Results There were significant differences（P 〈 0.05） in p53 and Bcl-2 expression rate between esophageal squamous tissue（42% and 68%） and normal tissue（12% and 10%）. The expressions of Bcl-2 protein was related with differentiated degree of esophageal squamous cancer（P 〈 0.05）, the expression of p53 protein was related with lymphatic metastasis. Chemoradiotherapy efficay in the p53 negative expression group was better than that in positive expression group（P 〈 0.05）. The expression of Bcl-2 protein has no relationship with chemoradiotherapy efficay of esophageal squamous cancer（P 〉 0.05）. Conclusion p53, Bcl-2 protein are related with the initiation and progression of esophageal squamous cancer, p53 protein can be the judging indicator of chemoradiosensitivity for esophageal squamous cancer patients.
出处
《兰州大学学报（医学版）》
CAS
2016年第4期43-46,共4页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省胃肠重点实验室科研项目(gswcky-2012-009)
