慢性肾脏疾病患者血清锌离子的变化及临床意义

Changes and clinical significance of serum zinc ions in chronic kidney diseases

目的 探讨慢性肾脏病患者血清锌离子的变化情况及临床意义。方法 选择2015年9～12月在本院收治的慢性肾脏疾病101例患者,并选择同期我院健康体检患者18例作为正常对照组,测定血清锌离子水平和常规生化测定肾功能、总蛋白、白蛋白等,并进行卡方检验、方差分析及Pearson相关性分析。结果 与正常对照组比较,CKD各期血锌降低,差异有统计学意义（P〈0.05）;与CKD 1期相比,CKD 2～5期血锌降低,差异有统计学意义（P〈0.05）;相关分析结果提示,血清锌离子与血磷水平呈显著负相关,与血清总蛋白、白蛋白和血钙水平呈正相关。结论 CKD患者体内血清锌离子水平降低,且与血磷、血清总蛋白、白蛋白和血钙有相关性,血锌降低可能与蛋白、血钙丢失、血磷沉积有关;纠正慢性肾脏病患者低血锌水平,有助于预防其并发症的发生。

Objective To discuss the changes and clinical significance of serum zinc ions in chronic kidney diseases （CKD）. Methods A total of 101 CKD patients treated in our hospital from September to Deceember 2015 were selected and another 18 healthy volunteer were enrolled into the control group. The level of serum zinc ions and routine biochemical parameters including renal function, total protein, and albumin were detected. The results were analyzed by chi-square test, variance analysis, and Pearson correlation analysis. Results Compared with the control group, the level of serum zinc ions was significantly lower in CKD patients at various stages （P〈0.05）. Compared with CKD patients at stage 1, the level of serum zinc ions was significantly lower in those at stage 2-5（P〈0.05）. The result of correlation anal- ysis indicated a significantly negative relation between the level of serum zinc ions and the level of serum phosphate, and a positive relation between the level of serum zinc ions and levels of serum total protein, albumin, and calcium. Conclusion CKD patients have a low level of serum zinc ions, which has relations with serum phosphate, total protein, albumin, and calcium. The reduction of serum zinc may be related to loss of protein and calcium and deposition of phosphate. Correction of the low level of serum zinc in CKD patients can help to prevent the incidence of complications.