羟考酮联合帕瑞昔布钠用于胃癌根治术后镇痛的临床效果

The clinical effect of oxycodone combined with parecoxib sodium for analgesia after radical resection of gastric cancer

目的 探讨联合羟考酮及帕瑞昔布钠用于胃癌根治术后镇痛的临床效果。方法 选择2014年6月~2015年12月在我院治疗的胃癌根治术患者74例为研究对象,按照住院单双号分为研究组和对照组各37例,研究组术后采用羟考酮联合帕瑞昔布钠镇痛,对照组术后采用吗啡联合帕瑞昔布钠镇痛,比较两组的镇痛效果及不良反应。结果 静息状态下,两组患者随着时间的延长,VAS评分均逐渐下降（P〈0.01）;在不同时间点,研究组患者VAS评分均显著低于对照组,差异有高度统计学意义（P〈0.01）。咳嗽状态下,两组患者随着时间的延长,VAS评分均逐渐下降（P〈0.01）;在不同时间点,研究组患者VAS评分均显著低于对照组,差异有高度统计学意义（P〈0.01）。研究组上腹部不适、恶心呕吐、嗜睡、皮肤瘙痒发生率显著低于对照组,其他镇痛药物追加比例显著低于对照组,差异有统计学意义（P〈0.05）。结论 联合羟考酮及帕瑞昔布钠用于胃癌根治术后镇痛效果确切,不良反应少,值得临床推广。

Objective To discuss the clinical effect of oxycodone combined with parecoxib sodium for analgesia after radical resection of gastric cancer. Methods A total of 74 cases with radical resection of gastric cancer from Jun 2014 to Dec 2015 were divided into study group（37 cases） and control group （37 cases） according to even and odd-numbered admission. Study group was treated with oxycodone combined with parecoxib sodium, and control group was treated with morphine combined with parecoxib sodium. Analgesic effect and adverse reaction of two groups were compared. Results Resting state, the two groups of patients with the extension of time, VAS scores were gradually decreased （P〈0.01）; At different time points, the VAS scores of the study group were significantly lower than that of the control group, the dif- ference was statistically significant （P〈0.01）. In coughing state, the two groups of patients with the extension of time, VAS scores were gradually decreased （P〈0.01）; At different time points, the VAS scores of the study group were signifi- cantly lower than that of the control group, the difference was statistically significant（P〈0.01）. In the study group, the incidence rates of abdominal discomfort, nausea, vomiting, drowsiness and pruritus were significantly lower than that of the control group, the proportion of other analgesic drugs was significantly lower than that of the control group, and the difference was statistically significant（P〈0.05）. Conclusion The clinical effect of oxycodone combined with parecoxib sodium for analgesia after radical resection of gastric cancer is of exact effect, with less adverse reactions, worthy of clinical promotion.