腹泻型肠易激综合征患者焦虑、抑郁状态与中医证型的相关性研究

Correlation study between TCM syndromes and psychological characteristics of anxiety and depression in patients with diarrhea irritable bowel syndrome

目的探讨腹泻型肠易激综合征(IBS-D)患者焦虑、抑郁状态与中医证型的相关性,为IBS-D治疗与心理调节提供依据。方法选取符合标准的250例IBS-D患者,根据中医证型将患者分为脾虚湿蕴证103例(A组)、肝郁脾虚证98例(B组)、脾肾阳虚证49例(C组)。由患者自行填写Zung抑郁自评量表(SDS)与焦虑自评量表(SAS),统计并分析不同证型IBS-D患者抑郁与焦虑的情况。结果 B组患者SDS、SAS评分均显著高于A组与C组(P<0.05)。B组患者中抑郁、焦虑以及抑郁合并焦虑状态患者均显著多于其他两组(P<0.05)。结论 IBS-D患者存在明显的抑郁与焦虑状态,且其中肝郁脾虚型的患者尤为突出。

Objective To integrative correlation between TCM syndromes with anxiety and depression in patients with diarrhea irritable bowel syndrome（IBS-D）, to provide basis of clinical treatment and psychological adjustment. Methods 250 patients with IBS-D were chosen and divided into Spleen Deficiency with Dampness Syndrome of 103 cases（Group A）, Liver-depression and Spleen-deficiency Syndrome of 98 cases （Group B） and Spleen and Kidney Deficiency Syn- drome of 49 Cases（Group C）. The Zung self-rating depressive scale（SDS） and self-rating anxiety scale（SAS） were filled and the results were analyzed. Results The SDS and SAS scores of Group B were significantly higher than Group A and Group C （P〈0.05）. Depression, anxiety and depression combined with anxiety patients in Group B were significantly more than other groups （P〈0.05）. Conclusion IBS-D patients, especially the Liver-depression and Spleen-deficiency Syndrome patients, have obvious depression and anxiety.