COPD稳定期患者接受健脾补肾汤后PARC/CCL-18含量、气道重塑程度以及MAPKs通路功能的评估

Assessment of PARC/CCL-18 content,degree of airway remodeling and MAPKs pathway function after stable COPD patients received Jianpi Bushen decoction

目的:分析COPD稳定期患者接受健脾补肾汤后PARC/CCL-18含量、气道重塑程度以及MAPKs通路功能。方法:选取90例在本院接受治疗的COPD稳定期患者,所有患者了解研究过程并签署知情同意书。对照组接受常规西医治疗,观察组接受健脾补肾汤联合常规治疗,对比两组循环血PARC/CCL-18含量、气道重塑相关指标水平及MAPKs通路功能差异。结果:观察组治疗后血清PARC/CCL-18含量低于对照组(P<0.05);观察组治疗后血清CTGF、b-FGF、TGF-β1、IL-25、Smad3、YKL-39、Activin A值均低于对照组(P<0.05);观察组接受治疗后的FEV1预计值、MMEF预计值高于对照组,T、AI、WA、WA%值低于对照组(P<0.05);观察组治疗后血清及诱导痰中MAPKs通路下游分子ERK、p38、c-Jun mRNA表达量均低于对照组(P<0.05)。结论:COPD稳定期患者接受健脾补肾汤治疗,可以有效抑制气道重塑进程,在促进微环境稳定的同时阻碍MAPKs通路功能,具有积极的临床意义。

[ABSTRACT]Objective：To analyze PARC/CCL-18 content,degree of airway remodeling and MAPKs pathway function after stable COPD patients received Jianpi Bushen decoction.Methods：A total of 90 cases of stable COPD patients received treatment in our hospital were enrolled in the study.Control group received conventional Western medicine treatment,observa-tion group received Jianpi Bushen decoction combined with conventional treatment,and then differences in circulating blood PARC/CCL-18 contents,airway remodeling-related index levels and MAPKs pathway function were compared between two groups.Results：Serum PARC/CCL-18 content of observation group after treatment was lower than that of control group （P 〈0.05）;serum CTGF,b-FGF,TGF-β1,IL-25,Smad3,YKL-39 and Activin A values of observation group after treatment were lower than those of control group （P 〈0.05）;predicated values of FEV1 and MMEF of observation group after treatment were higher than those of control group while T,AI,WA and WA% values were lower than those of control group （P 〈0.05）;the mRNA expression levels of MAPKs pathway downstream molecules ERK,p38 and c-Jun in serum and induced spu-tum of observation group after treatment were lower than those of control group （P 〈0.05）.Conclusion：Jianpi Bushen decoc-tion treatment of stable COPD patients can effectively inhibit airway remodeling process,promote microenvironment stability while hinder MAPKs pathway function,and it has positive clinical significance.