雷珠单抗联合光动力疗法对湿性年龄相关性黄斑变性患者视觉功能、敏感度及血清VEGF含量的影响

Effect of Lucentis combined with photodynamic therapy on visual performance and sensitivity as well as serum VEGF levels in patients with wet age-related macular degeneration

目的:分析雷珠单抗联合光动力疗法对湿性年龄相关性黄斑变性患者视觉功能、敏感度及血清VEGF含量的影响。方法:将在本院接受治疗的湿性年龄相关性黄斑变性患者78例(78眼)纳入研究,所有患者根据治疗方式不同随机分为观察组及对照组各39例。对照组单纯接受光动力疗法(PDT)治疗,观察组接受雷珠单抗联合光动力疗法治疗,对比两组视觉功能、敏感度及血清VEGF含量等差异。结果:观察组治疗后a、b波振幅、BCVA值高于对照组,CMT值低于对照组(P<0.05);观察组治疗后12月,100%、25%、10%、5%对比度下的对比度视力均低于对照组(P<0.05);观察组治疗后血清VEGF、PDGF值低于对照组,ES、ES/VEGF、ES/PDGF值高于对照组(P<0.05)。结论:雷珠单抗联合光动力疗法可以优化湿性年龄相关性黄斑变性患者的视觉功能、减少视网膜血管新生,具有积极的临床意义。

Objective：To analyze the effects of Lucentis combined with photodynamic therapy on visual performance and sensitivity as well as serum VEGF levels in patients with wet age-related macular degeneration.Methods：A total of 78 patients （78 eyes）with wet age-related macular degeneration who received treatment in our hospital were included for study and ran-domly divided into observation group and the control group （n =39）according to different treatment methods.Control group received photodynamic therapy （PDT）alone,observation group received Lucentis combined with photodynamic therapy,and then differences in visual performance and sensitivity as well as serum VEGF levels,etc were compared between two groups. Results：a-and b-wave amplitude and BCVA values of observation group after treatment were higher than those of control group,and CMT value was lower than that of control group （P 〈0.05）;contrast visual acuity under 100%,25%,10% and 5% contrast of observation group after 12 months of treatment were lower than those of control group （P 〈 0.05 ）;serum VEGF and PDGF values of observation group after treatment were lower than those of control group,and ES,ES/VEGF and ES/PDGF values were higher than those of control group （P 〈0.05）.Conclusion：Lucentis combined with photodynamic thera-py can optimize the visual performance in patients with wet age-related macular degeneration and reduce retinal neovasculariza-tion,and it has positive clinical significance.