TLR4炎症信号通路在高血压中的研究进展

The Research Progress of TLR4 Inflammation Pathway on Hypertension

随着高血压发病率的逐年提高,对高血压的研究也在不断增加。其中,对于慢性炎症反应在高血压发病中的作用机制,虽没有明确证实,但却是一个新颖并有价值的研究方向。诸多研究资料显示高血压是与免疫密切相关的、低度的全身炎症状态性疾病[1],高血压的发生、发展以及靶器官的损害,与血管炎症密不可分。因此,对于炎症信号通路的钻研及针对于此的药物的研发非常重要。Toll样受体4是广泛研究的炎症信号通路,以其为靶点来调控血压具有一定的疗效。本文将概述近些年来基于Toll样受体4信号通路对于治疗高血压的研究进展。

As the incidence of hypertension increased year by year, the study of hypertension is also growing. From now on, we can ＇t clearly make sure the role of chronic inflammation on the pathogenesis of hypertension mechanism, but it is a new and valuable re-search direction. Recent research showed that hypertension is closely related to immune and chronic inflammation, as well as the oc-currence and development of hypertension and target organ damage. So, this research has a significant impact on human health and drug discovery. As an inflammatory signaling pathway, TLR4 have certain effect on the control of hypertension. This article will sum-marize the research progress of TLR4 in the treatment of hypertension in recent years.