老年性痴呆中西医结合防治研究

Research on Integrated Traditional and Western Medicine in the Intervention and Treatment of Alzheimer's Disease

目的探讨中西医结合防治老年痴呆的临床疗效。方法收集老年性痴呆患者180例,随机分为2个组,醒智散联合安理申治疗组90例,安理申对照组90例。观察两组治疗前后的临床总有效率及MMSE、HDS、ADL、中医证候积分变化、血液流变学指标。结果治疗组总有效率为88.9%,明显优于对照组的64%(P<0.05)。治疗组治疗前后与对照组治疗前后相比MMSE、HDS评分均有明显提高,ADL评分明显下降,中医证候积分与血液流变学各项指标均有显著改善,且差异有统计学意义(P<0.05)。治疗后治疗组与对照组相比MMSE、HDS评分有显著提高,ADL评分下降显著,证候积分与血液流变学各项指标均显著改善,两组间比较差异有统计学意义(P<0.01)。结论中西医结合疗法可明显改善老年痴呆症状,防治疗效明显优于单纯西药治疗。

Objective To observe the clinical effect of integrated traditional and Western medicine in treating Alzheimer ＇s disease.Methods 180 elderly patients with Alzheimer＇s disease were randomly divided into treatment group（90 cases） and control group（ 90 cases）. The control group was treated with donepezil, and the treatment group was given Xingzhi powder based on the control group. The total clinical effect and the change of MMSE, HDS, ADL, Symptoms of TCM scores and hemorheological changes were observed. Results The total effective rate of the treatment group was 88.9% which was higer than 64% of control group（P〈0.05）.All patients＇ MMSE, HDS, Symptoms of TCM scores and hemorheological changes were significantly improved after treatment, ADL scores were significantly decreased than that before treatment, and the differences were statistically significant（ P〈0.05）. The improvement on MMSE, HDS, Symptoms of TCM scores and hemorheological changes of the treatment group after treatment were signifi-cantly than those of the control group, while the ADL scores were decreased remarkably, and the difference was statistically signifi-cant（ P〈0.05）. Conclusion The clinical effect of integrated traditional and Western medicine was better than single Western medicine in treating Alzheimer＇s disease.