李东垣脾胃病用药配伍的数据分析

Data Analysis on Compatibility Regularity of Li Dongyuan in Treating the Spleen and Stomach Disease

目的研究金代名医李东垣中药复方治疗脾胃病的药对配伍规律,为临床选药组方提供科学的理论指导。方法将金代名医李东垣《脾胃论》中治疗脾胃病的中医复方录入计算机,使用Microoft Office Excel2003软件建立中药复方数据库,运用统计学方法进行数据统计分析药对配伍规律。结果整理治疗脾胃病中药复方61首,涉及中药93种,筛选出甘草、陈皮、人参、白术、升麻、当归等前20味高频核心药物,统计得到药对1107对,而关联频度大于10次的33个。结论通过对高频药对的功效进行统计,得到治疗脾胃病的药对配伍特色:补虚药中的补气药、补血药与解表药中的发散风热药配伍;补虚药中的补气药、补血药与补虚药中的补气药配伍;理气药与补虚药中的补气药、补血药配伍;解表药与理气药、补虚药与清热药相须配伍;止咳化痰平喘药与理气药、补虚药配伍;化湿药与理气药、解表药、补虚药配伍。总结配伍的代表药对,为临床辨证脾胃病处方用药提供科学的理论依据。

Objective To study the compatibility regularity of Li Dongyuan of Jin Dynasty in treating the spleen and stomach disease with Chinese medicine compound formula, and to provide a scientific theoretical guidance for clinical selected medicine formula.Methods The compound Chinese medicine formula in Treatise on Spleen and Stomach of famous doctor Li Dongyuan in Jin Dynasty was input to the computer, Microoft office Excel 2003 software was used to establish the database of the Chinese medicine compound formula, and statistical methods for statistical data analysis of drug compatibility regularity was used. Results There were of 61 kinds of Chinese medicine compound formula in the treatment of spleen and stomach disease, involving 93 kinds of Chinese medicine,licorice root, dried orange peel, ginseng, white atractylodes rhizome, Cimicifuga rhizome, Chinese angelica, etc. of 20 kinds of highfrequency core drugs were screened, and there were 1107 couplet medicines, and associated frequency greater than 10 times were 33 couplet medicines. Conclusion Through the conclusion of high-frequency drugs on the efficacy of statistics, the combinations features were as follows： tonic medicine of tonifying qi, blood drug had compatibility with hot wind divergence of relieving exterior syndrome medicine, tonic medicine of tonifying qi and blood medicine had compatibility with tonic medicine of tonifying qi medicine, tonic medicine of tonifying qi and blood compatibility of medicines, drug and qi regulating drugs, tonifying qi and blood medicine in tonic deficiency drugs and regulating qi drug had compatibility, relieving exterior syndrome medicine, regulating qi medicine, tonic deficiency drugs and clearing heat medicine had compatibility each other, antitussive expectorant and antiasthmatic drugs had compatibility with regulating qi medicine and tonic deficiency drugs, resolving dampness medicine had compatibility with regulating qi medicine, relieving exterior syndrome medicine and tonic deficiency drugs. The representative couplet medicines were summarized,which provided a scientific basis for clinical syndrome differentiation of spleen and stomach disease.