换血治疗对52例重度高胆红素血症新生儿的疗效分析

Analysis of curative effect by blood exchange transfusion treatment for 52 newborn with severe hyperbilirubinemia

目的分析换血治疗对重度高胆红素血症新生儿疗效。方法 52例重度高胆红素血症新生儿采用换血治疗(全自动动静脉同步换血法),通过换血前、中、后血糖、急诊八项、胆红素各项指标变化,分析换血治疗的疗效。结果患儿换血前与换血中总胆红素、间接胆红素、血钾、血钠、血氯、总蛋白、血糖比较,差异有统计学意义(P<0.05);血钙、尿素、肌酐比较差异无统计学意义(P>0.05)。换血前总胆红素、间接胆红素、总蛋白[(505.00±81.46)μmol/L、(473.71±72.87)μmol/L、(51.95±4.26)g/L]与换血后[(166.79±58.91)μmol/L、(154.86±58.13)μmol/L、(46.34±4.51)g/L]比较,差异有统计学意义(P<0.05);血钾、血钠、血氯、血钙、尿素、肌酐、血糖比较差异无统计学意义(P>0.05)。患儿均治愈出院。结论换血治疗对新生儿重度高胆红素血症疗效显著,安全可靠,见效快,预后好。

Objective To analyze curative effect by blood exchange transfusion treatment for newborn with severe hyperbilirubinemia. Methods A total of 52 newborn with severe hyperbilirubinemia received blood exchange transfusion treatment （full-antomatic arteriovenous synchronous exchange transfusion）. Their curative effects were analyzed on the basis of changed indexes of blood glucose, emergency eight items and bilirnbin before, during and after exchange. Results The differences of total bilirubin, indirect bilirubin, serum potassium, serum sodium, serum chlorine, total protein and blood glucose had statistical significance before and during blood exchange （P〈0.05）, while the differences of serum calcium, urea and creatinine had no statistical significance （P〉0.05）. The difference of total bilirubin, indirect bilirubin, and total protein before exchange [（505.00 ± 81.46）μmol/L, （473.71± 72.87）μmol/L, （51.95± 4.26）g/L ] and after exchange [ （166.79 ± 58.91）μmol/L, （154.86 ± 58.13）μmol/L, （46.34 ± 4.51）g/L 1 had statistical significance （P〈0.05）. There was no statistically significant difference of erum potassium, serum sodium, serum chlorine, serum calcium, urea, creatinine and blood glueose （P〉0.05）. All children were healed and discharged. Conclusion Blood exchange transfusion treatment shows remarkably curative effect for newborn with severe hyperbilirubinemia. This method is safe and creditable,along with quick effect and good prognosis.