临床检验学中急性脑梗死患者的超敏C反应蛋白、同型半胱氨酸及脂蛋白a联合检测变化研究

Research of changes in combined detection of high-sensitivity C-reactive protein,homocysteine and lipoprotein a for acute cerebral infarction patients in clinical laboratory

目的探讨超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及脂蛋白a[LP(a)]与急性脑梗死的关系。方法检测68例脑梗死患者(急性脑梗死组)和100例健康人(健康对照组)血清超敏C反应蛋白、同型半胱氨酸及脂蛋白a的含量。结果急性脑梗死组超敏C反应蛋白、同型半胱氨酸、脂蛋白a含量[(11.28±5.17)mg/g、(19.1±4.7)μmol/L、(468±147)mg/g]明显高于健康对照组[(2.31±1.15)mg/g、(8.32±2.1)μmol/L、(196±81)mg/g](P<0.01)。结论超敏C反应蛋白、同型半胱氨酸、脂蛋白a与急性脑梗死的发生有关,三者同时检测对急性脑梗死的早期诊断疗效观察,预后判断具有重要的临床意义。

Objective To investigate relationship between high-sensitivity C-reactive protein （hs-CRP）, homocysteine （Hcy）, lipoprotein a[LP（a）]and acute cerebral infarction. Methods Detections of serum high-sensitivity C-reactive protein, homocysteine and lipoprotein a contents were made in 68 acute cerebral infarction patients （acute cerebral infarction group） and 100 healthy people （healthy control group）. Results The acute cerebral infarction group had all much higher high-sensitivity C-reactive protein, homocysteine and lipoprotein a contents[（11.28±5.17）mg/g, （19.1±4.7）μmol/L, （468±147）mg/g]than the healthy control group[（2.31±1.15）mg/g, （8.32±2.1）μmol/L, （196±81）mg/g]（P〈0.01）. Conclusion High-sensitivity C-reactive protein, homocysteine and lipoprotein a are related with occurrence of acute cerebral infarction. Combined detection of the three indexes contains important clinical significance for early diagnosis, curative effect observation and prognosis judgment in acute cerebral infarction.