降钙素原在外科感染性疾病中的临床应用价值

Clinical application value of procalcitonin in surgical infectious diseases

目的探讨降钙素原(PCT)在外科感染性疾病中的临床应用价值。方法 65例外科手术患者,根据出院诊断将其分为脓毒血症组(15例)、局部感染组(27例)、非感染对照组(23例)。比较入院当天的PCT差异。结果脓毒血症组及局部感染组PCT浓度[(15.62±12.17)、(4.39±3.52)ng/ml]均高于非感染对照组(0.45±0.16)ng/ml,差异均有统计学意义(P<0.05);脓毒血症组高于局部感染组(P<0.05)。结论 PCT可作为外科判断是否存在细菌感染及感染严重程度的可靠指标,并对合理使用抗生素有重要的参考价值。

Objective To investigate clinical application value of procalcitonin（PCT） in surgical infectious diseases. Methods A total of 65 patients, who received surgical operation, were divided by their discharge diagnosis into septicopyemia group（15 cases）, local infection group（27 cases） and non-infection control group（23 cases）. Comparison was made on difference of PCT between the groups. Results The septicopyemia group had the local infection group had all higher PCT concentration[（15.62±12.17） and（4.39±3.52） ng/ml]than（0.45±0.16） ng/ml in the non-infection control group. Their differences all had statistical significance（P〈0.05）. The septicopyemia group also had higher concentration than the local infection group（P〈0.05）. Conclusion As a creditable indicator, PCT can be taken in diagnosis of surgical bacterial infection and infection severity. It also contains important reference value for rational antibiotics use.