芦荟珍珠胶囊联合莫沙必利及复方嗜酸乳杆菌治疗便秘型肠易激综合征的疗效观察

Observation of curative effect by aloe pearl capsules combined with mosapride and compound lactobacillus acidophilus in the treatment of constipation-predominant irritable bowel syndrome

目的研究芦荟珍珠胶囊联合莫沙必利及复方嗜酸乳杆菌治疗便秘型肠易激综合征的疗效。方法 60例便秘型肠易激综合征患者,随机分为对照A组(应用复方嗜酸乳杆菌治疗)、对照B组(应用复方嗜酸乳杆菌及莫沙必利治疗)、实验组(应用复方嗜酸乳杆菌、莫沙必利及芦荟珍珠胶囊治疗),各20例。1周后比较三组疗效和不良反应情况。结果实验组总有效率(95%)高于对照A组(35%)及对照B组(70%),对照B组高于对照A组,差异均有统计学意义(P<0.05)。三组不良反应发生率比较,差异无统计学意义(P>0.05)。结论芦荟珍珠胶囊联合复方嗜酸乳杆菌和莫沙必利能安全有效治疗便秘型肠易激综合征。

Objective To research curative effect by aloe pearl capsules combined with mosapride and compound lactobacillus acidophilus in the treatment of constipation-predominant irritable bowel syndrome. Methods A total of 60 patients with constipation-predominant irritable bowel syndrome were randomly divided into control group A（receiving compound lactobacillus acidophilus for treatment）, control group B（receiving compound lactobacillus acidophilus and mosapride） and experimental group（receiving compound lactobacillus acidophilus, mosapride and aloe pearl capsules）, with 20 cases in each group. Comparison was made on curative effects and adverse reactions between the three groups after 1 week. Results The experimental group had higher total effective rate（95%） than control group A（35%） and control group B（70%）, while control group B had higher rate than control group A. Their differences all had statistical significance（P〈0.05）. There was no statistically significant difference of incidences of adverse reactions across the three groups（P〈0.05）. Conclusion Combination of aloe pearl capsules, compound lactobacillus acidophilus and mosapride is safe and effective in treating constipation-predominant irritable bowel syndrome.