期刊文献+

探讨氯吡格雷预防冠心病介入治疗心血管的临床疗效 被引量:1

下载PDF
导出
摘要 目的探究氯吡格雷预防冠心病介入治疗心血管的临床疗效。方法 70例冠心病介入治疗心血管疾病的患者,将其随机分为对照组(33例)和研究组(37例)。对照组行噻氯匹定治疗,研究组行氯吡格雷治疗,对比两组临床治疗效果。结果两组患者的术后凝血酶原时间、凝血酶时间以及纤维蛋白原等凝血功能指标比较,差异无统计学意义(P>0.05),对照组患者术后不良反应发生率为21.2%,明显高于研究组患者术后不良反应发生率6.4%(P<0.05)。结论氯吡格雷预防冠心病介入治疗心血管,对凝血功能无影响,利于降低术后不良反应发生率,可以推广应用。
作者 李霄 杨琳
出处 《中国实用医药》 2016年第24期147-148,共2页 China Practical Medicine
  • 相关文献

参考文献5

二级参考文献45

  • 1任艺虹,盖鲁粤,杨庭树,王洪叶,王禹,邢攸红,林琳,刘春雪.改良血栓弹力图法和流式细胞测定技术对血小板活性抑制程度的比较研究[J].中华心血管病杂志,2007,35(4):366-367. 被引量:37
  • 2Lev EI, Patel RT, Maresh KJ, et al. Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention : the role of dual drug resistance[ J ]. J Am Coil Cardiol, 2006,47:27-33.
  • 3Buonemici P, Marcucci R, Migliorini A, et al. Impact of platelet reactivity after clopidogrel administration on drug-eluting stem thrombosis[ J ]. J Am Coll Cardiol, 2007,4-9(24) :2312-2317.
  • 4Malek LA, Spiewak M, Filipiak KJ, et al. Persistent platelet activation is relat- ed to very early cardiovascular events in patients with acute coronary syndromes [J]. Kardiol Pol, 2007,65:40-45.
  • 5Laurent B, Laurence CJ. Adjusted clopidogrel loading doses according to vaso- dilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistence [ J ]. J Am Coll Cardiol, 2008,51(14) :1404-1411.
  • 6Malek LA, Bartlomiej MD, Spiewak M, et al. Coexisting polymorphisms of and genes as a risk factor for persistent platelet activation with clopidogrel [ J ]. Circulation, 2008,72(7) :1165-1169.
  • 7Fontana P, Hulot JS, Moerloose P, et al. Influence of CYP2C19 and CYP3A4 gene polymorphism on ciopidogrel responsiveness in healthy subjects [J]. Thromb Haemost, 2007,5(10) :2153-2155.
  • 8Kim KA, Park PW, Hong SJ, et al. The effect of CYP2C19 polymorphism on the phannacokinetics and pharmaeodynamics of clopidogrel: a possible mechanism for clopidogrel resistance[J]. Clin Pharmacol Ther, 2008,84:236-242.
  • 9Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment plateXet reactivity [ J ]. Circulation, 2003,107 (23) :2908 -2913.
  • 10Preis SR, Hwang SJ, Coady S, et al. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005 [ J ]. Circulation, 2009,119 (13) : 1728-1735.

共引文献52

同被引文献7

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部