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ADAM33基因rs2280090,rs487377,rs2787094多态性与哮喘的相关性研究 被引量：3

Association between ADAM33 polymorphisms and susceptibility of asthma
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摘要 目的:探讨ADAM33基因多态性与青岛地区汉族成人哮喘的相关性。方法:采用SNa Pshot方法检测研究对象ADAM33基因rs2280090、rs487377、rs2787094共3个位点的基因多态性。结果:rs2280090、rs487377和rs2787094基因型频率在哮喘组与对照组间差异无统计学意义(P>0.05)。结论:ADAM33基因rs2280090、rs487377和rs2787094多态性与青岛地区汉族成人哮喘无相关关系。 Objective： To investigate the relationship between ADAM33 polymorphisms and susceptibility of asthma of Chinese in Qingdao. Methods： The polymorphism of ADAM33 gene,they were rs2280090,rs487377 and rs2787094,were detected with Sna Pshot method. Results： There was no significant difference between asthma group and control group in genotypic frequencies. Conclusion： The study shows that the rs2280090,rs487377 and rs2787094 were not associated with susceptibility of asthma in Han nationality in Qingdao.
作者 薛卫林 周兆山 王燕青 吉中强 张小燕 梁文华
机构地区 山东省青岛市海慈医疗集团肺病科 山东省青岛市海慈医疗集团心内科 生物芯片国家工程研究中心
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2016年第8期1099-1102,共4页 Chinese Journal of Immunology
基金 国家自然科学基金资助项目(No.30873315) 山东省2015-2016年度中医药科技发展计划项目(No.2015-354)资助
关键词 哮喘 ADAM33基因 单核苷酸多态性 关联研究 Asthma ADAM33 Single nucleotide polymorphisms Association analyses
分类号 R392 [医药卫生—免疫学]
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参考文献13

  • 1Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness [ J]. Nature ,2002,418:426-430.
  • 2中华医学会呼吸病学分会.支气管哮喘防治指南[J].中华结核和呼吸杂志,2008,31:177-185.
  • 3梁文华,周兆山,吉中强,王燕青,薛卫林,张小燕.IL-4和IL-4R基因多态性与哮喘的相关性[J].中华医学遗传学杂志,2014,31(1):97-100. 被引量：18
  • 4Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity [ J ]. Trends Genet, 2000,16 (2) :83-87.
  • 5Yoshinaka T, Nishii K, Yamada K, etag. Identification and charac- terization of novel mouse and human ADAM33s with potential met- alloprotease activity [ J ]. Gene,2002,28 ( 1-2 ) :227-236.
  • 6Howard TD, Postma DS, Jongepier H, et al. Association of a disintegrin and metalloprotcase 33 ( ADAM33 ) gene with asthma in ethnically diverse populations [ J ]. J Allcriry Clin Immunol,2003, 112:717-722.
  • 7HirotaT, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population [ J]. Clin Exp Allcriry,2006,36:884-891.
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二级参考文献31

  • 1张爱民,李海林,陈燕华,郝萍,李继梅,莫亚雄,戴梅.白细胞介素4受体Q576R基因多态性与支气管哮喘的相关性[J].中华医学遗传学杂志,2005,22(2):231-232. 被引量：8
  • 2Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature,2002,418:426-430.
  • 3Werner M, Herbon N, Gohlke H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy, 2004,34:26-31.
  • 4Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in korean asthmatics. Clin Exp Allergy,2004,34:860-865.
  • 5Wolfsberg TG, Primakoff P, Myles DG, et al. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: muhipotential functions in cell-cell and cell-matrix interactions. J Cell Biol, 1995,131:275-278.
  • 6Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene,2002,282:227-236.
  • 7Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy ,2006,36:884-891.
  • 8Jongepier H, Boezen HM, Dijkstra A, et al. Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy,2004,34:757-760.
  • 9Simpson A, Maniatis N, Jury F, et al. Polymorphisms in a disintegrin and metalloprotease 33 ( ADAM33 ) predict impaired early-life lung function. Am J Respir Crit Care Med ,2005,172:55- 60.
  • 10Masoli M,Fabian D, Holt S, et al. The global burden of asthma: exeeutive summary of the GINA Dissemination Committee report [J]. Allergy, 2004,59:469-478.

共引文献41

同被引文献26

引证文献3

二级引证文献4

中国免疫学杂志
2016年 第8期

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