血府逐瘀胶囊对宫腔粘连的相关激素表达的影响及临床疗效

The effect of Xuefuzhuyu capsule on the expression of related-hormone of intrauterine adhesion and its clinical efficacy

目的:探讨血府逐瘀胶囊对宫腔粘连形成中相关激素表达的影响及临床疗效。方法:纳入北京市第一中西医结合医院2013年1月至2014年11月闭经或月经过少的门诊收住院患者,通过宫腔镜确诊为宫腔粘连并分离粘连后,在术中放置节育环的女性220例,随机平均分为2组,对照组110例戊酸雌二醇2 mg口服,1次/天,观察组110例口服血府逐瘀胶囊;同时选取100名健康体检者作为健康组。分别观察每组受试者术后月经量、宫腔镜下宫腔情况。测定受试者的黄体生成素、血清卵泡刺激素、雌二醇、孕酮、催乳素和睾酮水平,以及雌激素受体(ER)、孕激素受体(PR)的表达。结果:2组均在3个月内停药,取环均获得成功。对照组总有效率74.55%,观察组为98.18%,2组疗效差异无统计学意义(P>0.05);2组患者治疗后6项激素水平差异均无统计学意义(P>0.05);2组子宫内膜ER和PR的表达水平均明显高于健康组(P<0.01)。结论:子宫内膜中ER、PR的异常表达可能参与宫腔粘连的形成,血府逐瘀胶囊同戊酸雌二醇一样,对治疗宫腔粘连效果显著。

Objective： To investigate the effects of Xuefuzhuyu capsule（ XFZYC） on the expression of related-hormone of intrauterine adhesion and its clinical efficacy. Methods： The patients with amenorrhea or scanty menstruation from ＂ The First Hospital of Traditional Chinese and Western Medicine of Beijing＂ from Jan 2013 to Nov 2014 were diagnosed by hysteroscopy,and their intrauterine adhesion was separated. Two hundred and twenty women placed with the contraceptive ring were randomly divided into the control group and observation group（ 110 cases each group）. The control group and observation group were treated with 2 mg of estradiol valerate and XFZYC by oral,once a day,respectively. One hundred healthy women were set as the healthy group. The postoperative volume of menstrual flow and intrauterine condition under hysteroscopy in all groups were observed. The levels of luteinizing hormone（ LH）,follicle stimulating hormone,estradiol,progesterone,prolactin and testosterone,and the expressions of estrogen receptor（ ER） and progesterone receptor（ PR） were detected. Results： Among two groups,the drug use stopped within three months,and taking ring was successful. The total effective rates in the control group and observation were 74. 55% and 98. 18%,respectively,the difference of which was not statistically signifcant（ P〈0. 05）. The differences of the 6 stems hormone levels between two groups after treatment were not statistically signifcant（ P〉0. 05）. The expression of endometrium ER in two groups was higher than that in healthy women（ P〈0. 05）. Conclusions： The abnormal expression of endometrium ER and PR may be involved in the formation of intrauterine adhesion.The effect of XFZYC in the treatment of intrauterine adhesion is significant.