摘要
目的探讨宫颈癌患者D-二聚体(D-D)、纤维蛋白原(FIB)水平及其与临床病理特征的关系。方法回顾性分析98例初治宫颈癌患者(宫颈癌组)及52例宫颈良性病变患者(对照组)的临床病理资料。比较治疗前两组患者的基线D-D及FIB水平,分析宫颈癌患者D-D及FIB阳性率与临床病理特征的关系。结果宫颈癌组D-D、FIB阳性率均高于对照组(P<0.05);宫颈癌组高龄患者(年龄≥60岁)、功能状态评分≤70分者、存在淋巴结转移者的基线D-D、FIB阳性率均升高(均P<0.05),随着临床分期的增高,D-D、FIB阳性率亦呈增高趋势(P<0.05)。结论宫颈癌患者易处于高凝状态,且以高龄者、体能状况差者、临床分期晚期者、有淋巴结转移者明显。高凝状态宫颈癌患者可能预后不良。
Objective To explore the levels of D-dimer（D-D） and fibrinogen（FIB） ,and their relationship with clinicopathological features in patients with cervical cancer. Methods The clinicopathalogical data of 98 initially treated patients with cervical cancer（ cervical cancer group） and 52 patients with cervical benign lesion（ control group） were retrospectively analyzed. The baseline levels of D-D and FIB were compared between the two groups, and the relationship of positive rates of D-D and FIB with clinicopathological features in patients with cervical cancer was analyzed. Results The positive rates of D-D and FIB in the cervical cancer group were significantly higher than those in the control group （ P 〈 0.05 ）. In the cervical cancer group, the positive rates of baseline D-D and FIB increased in the patients with advanced age（ 960 years）, Karnofsky score 470 and lymphatic metastasis （P 〈 0.05 ）. The positive rates of D-D and FIB obtained increasing trend with the increase of clinical stage （P 〈 0.05 ）. Conclusion The patients with cervical cancer easily suffer from hypercoagnlability, especially the patients with advanced age, poor physical condition, advanced clinical stage and lymphatic metastasis. Poor prognosis might be observed in cervical cancer patients with hypercoagnlability.
出处
《广西医学》
CAS
2016年第9期1242-1244,共3页
Guangxi Medical Journal
基金
新疆维吾尔自治区人民医院院内科研项目(20150117)
