国内单中心1321例结直肠癌预后的临床分析

The prognosis of colorectal cancer—the analysis of statistics of 1 321 cases from a single clinic center in China

目的探讨中西方结直肠癌治疗及预后的差别。方法对本中心的1 321例结直肠癌患者临床病例资料及随访数据进行分析,并与Surveillance,Epidemiology and End Resluts(SEER)数据库和European Cancer Registry(EUROCARE-4)数据库进行比较,研究中西方结直肠癌预后的差异。结果 1 321例接受结直肠癌切除手术患者5年总生存率为62.6%,高于中国平均水平(47.2%),与SEER数据库的64.7%和EUROCARE-4的56.8%相似。各分期中,与SEER数据比较,入组数据虽然生存率较低,但分期方式受到新辅助治疗降期等因素影响,其差异不能说明预后更差。结论本中心结直肠癌手术患者预后好于中国结直肠癌患者预后的平均水平,与西方国家结直肠癌患者预后相似。

Objective To compare the differences in prognosis between statistics of different databases from China and western countries. Methods One-thousand-three-hundred-and-twenty-one patients with colorectal cancer underwent surgery in our clinic center. We analyzed the clinical characteristics and prognosis of these patients and compared these data with the statistics of SEER and EUROCARE-4. Results The rate of 5-year overall survival was 62. 6% in our clinic center. It was higer than the average level（ 47. 2%） of clinic centers in China and similar to the statistics of Surveillance,Epidemiology and End Resluts（ SEER） and European Cancer Registry（ EUROCARE-4） database（ 64. 7%,56. 8%,respectively）. The prognosis according different stages was worse than SEER,which could be due to the effect of neoadjuvant radiotherapy. Conclusion The prognosis of patients with colorectal cancer in our clinic center was better than the average level of clinic centers in China and similar to the prognosis in western world.