2型糖尿病患者血清25-羟维生素D3与肾功能的关系分析

The association of 25-OH-vitamin D3 with renal function in type 2 diabetic patients

目的探讨2型糖尿病患者25-羟维生素D3水平与肾功能的相关关系。方法选择2014年1～3月在该院内分泌科住院的2型糖尿病患者74例，测量其体质量、身高、血压、血清25-羟维生素D3、甲状旁腺激素（PTH）、糖化血红蛋白、血肌酐、尿蛋白／尿肌酐及肾小球滤过率（GFR）等。所有患者按25-羟维生素D3水平分为3组：维生素D3缺乏组（〈20nm01／L）8例，维生素D3不足组（2050nmol／L）54例，维生素D3正常组（〉50nmol／L）12例，观察维生素D3水平与血肌酐的相关关系。结果与维生素D3正常组相比较，维生素D3缺乏组及不足组血肌酐水平显著增高（P〈0．05），且血清血肌酐水平与25-羟维生素D3水平呈负相关。结论2型糖尿病患者中维生素D3缺乏与肾功能恶化相关。

Objective To evaluate the association between 25-OH-vitamin D3 and renal function in type 2 diabetic patients. Methods A total of 74 patients with type 2 diabetes in our hospital from January to March 2014, were enrolled. Body weght, height,blood pressure, 25-OH-vitamin D3,PTH, HbA1C, Scr, urinary albumin creatinine rano and GFR were measured. Patients were divided into vitamin D3 deficiency （〈20 nmol/L,n=-8） group,vitamin D3 insufficient group （20--50 nmol/L,n= 54） and vi- tamin D3 sufficiency group （〉50 nmol/L,n= 12） according to the levels of vitamin D3. The relationship between Scr and vitamin D3 was analyzed. Results Compared with the vitamin D3 sufficiency group, Scr level in vitamin D3 deficiency group and insufficen- cient group was significantly increased（P〈0.05）. The Vitamin D3 concentration was negatively correlated with Scr. Conclusion The deterioration of renal function was strongly associated with vitamin D3 in type 2 diabetic patients.