大剂量糖皮质激素对重症蜂蜇伤患者预后的影响分析

Application of high-dose glucocorticoid on the prognosis of patients with severe wasp sting

目的探讨大剂量糖皮质激素对重症蜂蜇伤患者的疗效及预后。方法选取2012年3月至2014年12月在川北医学院附属医院收治的重症蜂蜇伤患者57例作为研究对象,根据糖皮质激素用量分为甲强龙冲击组(观察组,27例)与常规剂量甲强龙组(对照组,30例)。比较两组患者肝、肾功能与尿常规指标,观察并记录住院时间、肾功能恢复时间及病死率。结果入院第1天两组患者的总胆红素(TB)、丙氨酸氨基转移酶(ALT)、血清肌酐(Scr)比较差异均无统计学意义(P>0.05),入院第7天两组患者的各项生化指标与入院第1天比较差异均有统计学意义(P<0.05)。观察组住院时间、肾功能恢复时间均明显小于对照组,差异有统计学意义(P<0.05)。结论甲强龙冲击对重症蜂蜇伤治疗效果更好,能促进患者受损器官功能的恢复,缩短患者住院时间,降低患者的住院费用。

Objective To study the effect and prognosis of high-dose glucocorticoid on patients with severe wasp sting. Methods Totally 57 cases of patients with severe wasp sting from March 2012 to December 2014 were selected in hospital as re- search objects. According to different dosages Of methylprednisolone, patients were divided into following two groups： high-dose methylprednisolone group （observation group,27 cases） and general methylprednisolone group （control group,30 cases）. The liver and kedney functions, urine general indexes, hospital stays, complete recovery time of the kidney functions, and patients mortalities were compared. Results In the 1st day of admission in hospital,TB,ALT,Scr and red blood cell in urine of patients in two groups showed no significant statistical difference （P〉0.05）. In the 7th day of the hospital stay, the biochemical indexes of the two groups,compared with the indexes on the first day,displayed significant differences （P〈0.05）. The average time of hospital stay and recovery of renal function in the observation group were significantly less than those of the control group, the difference was statistically significant（P〈0. 05）. Conclusion Methylprednisolone pulse therapy for severe bee sting injury and the therapeutic effect is better, can promote patients with impaired organ function recovery, shorten the patient＇s hospitalization time, reduce the patient hospitalization expenses.