2型糖尿病及其药物对心房颤动的影响

Effect of Type 2 Diabetes Mellitus and Diabetic Drugs on Atrial Fibrillation

糖尿病作为心血管疾病的重要风险因素,也是老年人群中常见的慢性疾病之一。大部分心血管疾病如冠心病、高血压、心肌病等随着病程的进展往往可发展为心房颤动。已有证据显示,糖尿病可通过影响心脏的自主神经重构、电重构及结构重构诱发心房颤动;而在糖尿病患者中,心房颤动也是其全因死亡率和心血管发病率的独立危险因素。了解糖尿病在心房颤动发病中的作用及各种降糖药对心房颤动的影响将有助于理解糖尿病和心房颤动的相关性,并更好地对合并心房颤动的糖尿病患者进行管理。

Diabetic mellitus is one of the most common chronic diseases for the senior population and presents one of the most important risk factors for cardiovascular disease. Most cardiovascular disease such as coronary artery disease,hypertension and cardiomyopathy will develop to atrial fibrillation（ Af） with the progress of primary disease. Evidence has proven that Af is a strong and independent cause of death and cardiovascular morbidity in diabetic patients. Additionally that diabetic mellitus could promote the initiation and maintenance of Af by causing the autonomic,electrical and structural remodelling of the atrium. It will help us to understand the relationship between diabetic mellitus and Af and make better decisions regarding the management of these patients by reviewing the potential pathology of Af in the setting of diabetic and the influence of current available anti-diabetic drugs to Af.