锚蛋白B在心血管系统中作用的研究进展

Research Progress of Ankyrin-B in Cardiovascular System

锚蛋白家族是重要的整合蛋白,参与心血管系统中离子通道、跨膜蛋白在细胞膜上的固定及适当表达和功能维持。锚蛋白通路的缺陷可以导致离子通道和跨膜复合物的功能异常并引发致死性心律失常,如锚蛋白B综合征。近来研究还发现锚蛋白B的水平在心肌梗死后及窦房结病变中有显著变化,提示锚蛋白B与人类心血管疾病密切相关。对锚蛋白的研究为了解人类心血管疾病提供了新的分子机制。现就近年来锚蛋白B在心血管系统的研究进展做扼要概括。

Ankyrins are a family of＂adaptor＂proteins,and play critical roles in the proper expression and membrane localization of ion channels and as transporters in the cardiovascular system. Dysfunction in ankyrin- based pathways has been linked with abnormal ion channel and transporter membrane organization and fatal human arrhythmias,including ankyrin-B syndrome. Additionally ankyrin-B levels have been shown to be significantly affected following myocardial infarction and sinus node dysfunction（ SND）. These findings suggest that ankyrin dysfunction has been associated with human cardiovascular disease phenotypes. Advances in ankyrin research will generate new insights into the molecular biological mechanisms to understand human cardiovascular disorders. In this review,we will briefly introduce recent ankyrin-B research advance in the cardiovascular system.