力竭运动对心肌组织结构及功能影响的研究进展

Research Progress of Effect of Exhaustive Exercise on Structure and Function of Cardiac Muscle

目前大量研究显示力竭运动可对机体心肌组织结构及功能造成损害,导致心肌组织结构紊乱,并可进一步造成心脏传导系统异常及收缩功能障碍等多种损伤,许多分子机制,如氧化应激、细胞凋亡、钙超载、能量代谢障碍、细胞因子分泌紊乱等,在上述损伤中扮演着重要角色,通过对这些损伤机制的深入研究,可进一步找到保护运动性心肌损伤的方法。

At present,a large number of studies show that exhaustive exercise on the myocardial tissue structure and function of the body causes damage. This results in myocardial tissue structure disorder,and causes further injury of cardiac conduction system abnormalities and systolic dysfunction and other damages. Many molecular mechanisms are also damaged,such as oxidative stress,apoptosis,calcium overload and energy metabolism disorder and cytokine secretion disorders and they play an important role in the injury. In-depth study on the damaged mechanism can further help to find a way to protect the exercise-induced myocardial injury.