纯镁超声微弧氧化-植酸-丝素复合处理种植体的体内降解特性

Degradation characteristics of pure magnesium ultrasonic micro-arc oxidation-phytic acid-fibroin composite coating

目的为了实现纯镁种植体在体内的降解特性可调控,并赋予材料表面活性,将纯镁超声微弧氧化膜层进行植酸封孔后再进行丝素沉积,研究其可降解和骨生长关系。方法纯镁MAO种植体为对照A组、纯镁MAO-植酸复合膜层种植体为实验B组、纯镁MAO-植酸-丝素蛋白复合膜层种植体为实验C组。将三种种植体植入兔下颌骨内,通过血尿镁离子测定检查、CBCT、SEM扫描电镜来观察不同种植体的降解特性和骨愈合情况。结果血尿镁离子测定检查都在正常的范围,CBCT显示骨愈合情况C组>B组>A组,SEM电镜显示降解速率A组>B组>C组。3组的实验结果都具有统计学意义。结论三组材料相比较,纯镁MAO-植酸-丝素蛋白复合处理的种植体减缓降解速率,有利于骨固定促进骨愈合最佳。

Objective In order to realize regulating degradation characteristics and obtaining surface activity for pure magnesium implanted in a body, pure magnesium ultrasonic micro-arc oxide film layer is treated with phytic acid for sealing hole and silk fibroin deposit. The relationship between degradation and bone growth was researched. Methods ultrasonic micro-arc oxidation group （group A, experiment is done with three groups： the pure magnesium control group）, the pure magnesium ultrasonic micro-arc oxidation-phytic acid composite coating implant（group B, experimental group）, the pure magnesium ultrasonic micro-arc oxidation-phytic acid-silk fibroin composite coating implant （group C, experimental group）. We implanted the processed pure magnesium implants into mandibles of rabbits and observed them in 2 weeks and 6 weeks. Then, we executed the experimental animals by air embolism. We ob- served the bone healing and the degradation of the compound processing pure magnesium implants by gross observation, checking of hematuria determination of magnesium ions, Cone beam CT and scanning electron microscope. Results M from CBCT results is C 〉 B 〉 agn A. esium ions is in the normal range. Bone tissue growth fir these groups The scanning electron microscopy showed that the degradation rate of groups is A 〉 B 〉 C. Three groups of experiment results are all statistically significant. Conclusions By comparing three groups of materials, we found that pure magnesium with ultrasonic micro-arc oxidationphytic acid-silk fibroin composite processing performs best in slowing degradation rate and promoting bone healing.