86例卡前列素氨丁三醇注射液不良反应报告分析

Analysis of 86 cases of adverse reactions of carboprost tromethamine injection

目的 分析和探讨卡前列素氨丁三醇注射液不良反应的发生情况,为临床安全用药提供参考。方法 采用回顾性研究方法,收集我院2008年1月~2015年12月发生并上报的86例卡前列素氨丁三醇注射液不良反应进行统计分析。结果 患者的给药总剂量均在正常剂量范围内,给药途径为肌肉注射和子宫肌层注射两种,不良反应的出现以肌内注射居多。不良反应发生时间最短在注射卡前列素氨丁三醇后3 min出现,最长在注射卡前列素氨丁三醇后26 h后出现。不良反应以腹泻、血压升高、恶心、呕吐等为主,有11例同时出现两种不良反应。1例有支气管哮喘病史者肌注卡前列氨丁三醇注射液约65 min后,出现胸闷气喘、呼吸困难、气促的不良反应。不良反应均不严重,给予对症处理后,均能得到缓解,不影响产妇的预后。结论 卡前列氨丁三醇注射液存在迟发型不良反应,即使在正常用法用量下,也应注意监测不良反应。对有严重高血压、哮喘和肺部疾患的产妇,应尽量避免使用该药。

Objective To analyze and explore the incidence of the adverse reactions of carboprost tromethamine injection to provide reference for safe clinical drug application. Methods A total of 86 cases of adverse reactions of carboprost tromethamine injection, which occurred early or late from January 2008 to December 2015 in our hospital and were reported, were selected for statistical analysis by retrospective study method. Results The total dose for patients was within the normal dose range; the routes of administration included intramuscular （IM） injection and myometrium injection; most adverse reactions happened to IM injection. The earliest adverse reactions happened 3 minutes after the injection of carboprost tromethamine and the latest 26 h after the injection. Adverse reactions mainly include diarrhea, elevation of blood pressure, nausea and vomiting. 11 patients had two adverse reactions simultaneously. One patient with history of bronchial asthma had wheezing ＆ tightness in chest, dyspnea and polypnea 65 min after the injection. All adverse reactions were not severe and were relieved after expectant treatment without affecting the prognosis of puerpera. Conclusion Carboprost tromethamine injection may cause delayed adverse reactions, thus adverse reactions shall be monitored even under normal usage and dosage. Administration of the drug shall be avoided for puerpera with severe hypertension, asthma and pulmonary diseases as much as possible.