密封系统对低频超声透皮给药的影响

Influence of Sealed System in Low Frequency Sonophoresis

为提高低频超声透皮给药过程中药液渗透率的控制精度,通过有限元计算分析,设计了一款具有密封结构的超声换能器,用以改变低频超声透皮给药系统中的药液压强。基于Franz扩散池的皮肤透皮体外实验的研究(包括人造皮肤与大鼠离体皮肤),获得了密封系统对透皮渗透量变化的影响规律。实验结果表明,超声空化、促渗剂与压强都可以改变药液渗透率,其中超声可以通过空化效应破坏皮肤表层结构进而促进渗透,而压强与超声、促渗剂相互结合则可以起到提高给药渗透精度的作用。提出的密封式超声换能器可通过压强变化初步实现调节低频超声透皮给药精度的目的,为进一步设计可调压强的低频超声给药系统奠定应用基础。

Aiming at improving controlling precision of drug permeation in low frequency sonophoresis(LFS),an ultrasonic transducer with sealed structure is designed to change the pressure of drug liquid in LFS,based on finite element calculation and analysis.The influence of sealed system on transdermal process can be investigated by vitro experiments on skins(including artificial skins and rat skins)permeation through a Franz diffusion cell system.The results demonstrate that ultrasonic cavitations,penetration enhancers and the pressure can change the permeability of skin.Ultrasound can damage the surface structure on the skin to increase the permeation due to the ultrasonic cavitations,and the pressure,ultrasound and penetration enhancers can be used to improve the accuracy of drug penetration effect together.Therefore,this ultrasonic transducer with a sealed structure can preliminarily realize pressure change in LFS to adjust the precision of transdermal drug delivery,which can be beneficial for the further design of ultrasonic transducer with controlled pressure in LFS applications.