艾灸盒温灸对阳虚体质者症状及血清cAMP/cGMP比值的影响

Effects of the Warming Box-Moxibustion on the Symptom and the Ratio of Serum cAMP/cGMP in the Subjects with Yang Deficiency Constitution

目的观察艾灸盒温灸疗法对阳虚体质者症状及血清环磷酸腺苷(c AMP)/环磷酸鸟苷(c GMP)比值的影响,探究阳虚体质与c AMP/c GMP比值的相关性。方法将90例阳虚体质受试者随机分为灸盒组、参附液组、肾气丸组,每组30例,3组均以7 d为1个疗程,连用4个疗程。根据治疗后受试者阳虚质判定评分量表的得分情况评价疗效,同时观察治疗前后血清c AMP/c GMP比值变化情况。结果治疗后,3组受试者阳虚体质转化分均较前显著下降(P<0.01),灸盒组下降程度高于参附液组和肾气丸组(P<0.05);3组受试者血清c AMP/c GMP比值均较前下降(P<0.05),其中灸盒组下降幅度最高(P<0.05);灸盒组总有效率为53.3%,参附液组总有效率为43.3%;,肾气丸组总有效率40.0%,3组整体疗效相当(P>0.05)。结论艾灸盒温灸能显著改善阳虚体质,c AMP/c GMP与阳虚体质存在一定的相关性。

Objective To observe the wanning box-moxibustion＇s effect on symptoms of Yang deficiency constitution and investigate its correlation with on cAMP/cGMP ratio. Methods A total of 90 Yang deficiency constitution subjects were assigned to warming box-moxibustion group, Shenfu liquid group and Shenqi pill group, 30 cases in each group, the groups were given four 7--day courses consecutively. Then the scores of yang deficiency CCMQ （Constitution in Chinese Medicine Questionnaire） were evaluated and the change of cAMP/cGMP ratio before and after treatment was observed. Results The yang deficiency CCMQ scores of the three groups were decreased after treatment （P〈0.01）. The decrement of yang deficiency CCMQ scores in box-moxibustion group was higher than those in Shenfu liquid group and Jinkuishenqi pill group （P〈0.05）. The cAMP/cGMP ratio in serum of the three groups reduce significantly after treatment （P〈0.05）. The cAMP/cGMP ratio in box-moxibustion group has the highest extent of reducing （P〈0.05）. After treatment, the total effective rate in box-moxibustion group was 53.3%, while in Shenfu liquild group was 43.3%, and Shenqi pill group was 40.0%; while comparing the overall curative effect of the three groups, there was no statistically significant difference （P〉0.05）. Conclusion Warming box-moxibustion can significantly improve Yang deficiency constitution, and there was some correlation between cAMP/cGMP and yang deficiency constitution.