脂蛋白相关磷脂酶A2检测对冠心病风险判断的价值

Value of lipoprotein associated phospholipase A2 detection in risk judgment of coronary heart disease

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平和冠心病患者冠状动脉狭窄程度的相关性和临床意义。方法将243例冠心病和疑似冠心病患者根据冠状动脉造影检查结果分为高危风险组(至少1支冠状动脉狭窄程度>50%,102例)和低危风险组(单支冠状动脉狭窄程度≤50%,141例),收集患者临床资料,采用ELISA检测受试者Lp-PLA2水平,进行对比分析。结果高危风险组受试者血清Lp-PLA2水平显著高于低危风险组,差异有统计学意义(P<0.01)。Lp-PLA2判断冠心病高危患者的灵敏度为86.3%,特异度为96.6%,总诊断准确度为98.0%。结论 Lp-PLA2可较好地评估冠心病患者风险,血清Lp-PLA2水平可反映冠状动脉病变严重程度。

Objective To investigate the correlation between serum lipoprotein associated phospholipase A2（Lp-PLA2）level and severity of coronary artery stenosis in the patients with coronary heart disease（CHD）and its clinical significance.Methods A total of 243 cases of CHD and suspected CHD were divided into the high-risk group（at least 1 coronary artery vessel stenosis 50%,n=102）and low-risk group（single coronary artery vessel stenosis≤50%,n=141）according to the coronary angiography results.The clinical data were collected and Lp-PLA2 level was detected by ELISA.Results The serum Lp-PLA2 level in the highrisk group was significantly higher than that in the low-risk group,and the difference was statistically significant（P0.01）,the sensitivity of Lp-PLA2 for judging the high-risk patients with CHD was 86.3%,the specificity was 96.6%,and the overall diagnosis accuracy was 98.0%.Conclusion Lp-PLA2 can better assess the risk of CHD patients and the serum Lp-PLA2 level can reflect the severity of coronary artery lesion.