杭州地区孕妇全血微量元素正常参考值研究

Investigation on reference values of whole blood trace elements among pregnant women in Hangzhou area

目的建立杭州地区孕妇全血微量元素正常参考值,为确保孕妇及胎儿健康提供临床诊断依据。方法随机收集杭州市某综合性医院2015年入院待产的孕妇静脉血122份,采用电感耦合等离子体质谱仪检测铅、镉、铜、锌、镍、铬、铍、锰、钴、砷、钼、钛和铊13种微量元素水平,并对其进行统计分析。结果孕妇全血铜、铬、锰和钛结果为正态分布。按±1.96s确定5%-95%参考区间,杭州地区孕妇全血铜、铬、锰和钛的参考区间分别为255.37-668.23、56.09-151.93、18.46-54.60、800.90-2 632.02μg/L。结论制订孕妇全血微量元素正常参考值,对临床医生为本地区孕妇提供营养保健指导和掌握其体内重金属污染水平具有重要的意义。

Objective To establish the normal reference intervals of whole blood trace elements among pregnant women in Hangzhou area to provide the clinical diagnostic basis for ensuring the health of pregnant women and their fetuses.Methods A total of 122 whole blood samples in pregnant awaiting delivery in a general hospital of Hangzhou City during 2015 were collected randomly.The levels of lead（Pb）,cadmium（Cd）,copper（Cu）,zinc（Zn）,nickel（Ni）,chromium（Cr）,beryllium（Be）,manganese（Mn）,cobalt（Co）,arsenic（As）,molybdenum（Mo）,thallium（Ti）and thallium（Tl）were determined with ICP-MS.And the results were statistically analyzed.Results The detection results of whole blood Cu,Cr,Mn and Ti showed a normal distribution.The 5%-95% reference interval was determined according to ±1.96 s,the normal reference intervals for these 4 elements were 255.37-668.23,56.09-151.93,18.46-54.60 and 800.90-2 632.02μg/L respectively.Conclusion Formulating the normal reference values of whole blood microelements levels has an important significance for clinical doctors to provide the nutritional health care guidance and master the heavy metal pollution level.