乳腺癌患者血清TK1、CA153、CEA的变化及临床意义

Changes and clinical significance of serum TK1,CA153,CEA in breast cancer patients

目的探讨胸苷激酶1(TK1)、糖类抗原(CA)153、癌胚抗原(CEA)在乳腺癌患者血清中的变化情况及临床意义。方法选择92例住院治疗的乳腺癌患者,66例乳腺良性疾病患者和50例健康体检者,分别检测各组血清TK1、CA153、CEA水平,用单因素分析法分析血清TK1、CA153、CEA水平与乳腺癌病理参数的关系。结果乳腺癌组血清TK1、CA153、CEA水平显著高于乳腺良性疾病组和对照组,差异均有统计学意义(P<0.05)。血清TK1、CA153、CEA水平与乳腺癌病理分期、淋巴结转移等因素相关(P<0.05)。结论 TK1、CA153、CEA水平升高对乳腺癌的诊断、浸润、转移及严重程度具有重要临床意义。

Objective To investigate the changes and clinical significance of serum thymidine kinase 1（TK1）,carbohydrate antigen 153（CA153）and carcinoembryonic antigen（CEA）in the patients with breast cancer.Methods The levels of serum TK1,CA153 and CEA were detected in 92 inpatients with breast cancer,66 patients with benign breast disease and 50 people undergoing the physical examination.The relationship between serum TK1,CA153 and CEA with the pathologic parameters in breast cancer was analyzed by the single factor analysis method.Results Serum TK1,CA153 and CEA levels in the breast cancer group were significantly higher than those in the benign breast disease group and control group,the differences were statistically significant（P〈0.05）.The serum TK1,CA153 and CEA levels were related with the degree of pathological stage and lymph node metastasis（P〈0.05）.Conclusion The increase of serum TK1,CA153 and CEA levels has an important clinical significance in the diagnosis,infiltration,metastasis and severity of breast cancer.