血清RBP、凝血四项和血小板指标检测在重症肝病辅助诊断中的应用

Application of testing serum RBP,coagulation four indexes and platelet parameters in auxiliary diagnosis of severe liver disease

目的探讨血清视黄醇结合蛋白(RBP)、凝血四项和血小板指标检测在重症肝病辅助诊断中的应用价值。方法随机选取2014年1月至2015年12月该院门诊及住院收治的110例重症肝病患者[43例急慢性重症肝炎患者(A组),36例肝硬化患者(B组)和31例肝癌患者(C组)]、38例非重症肝病患者和40例健康体检者(对照组)作为研究对象,对研究对象进行RBP、凝血四项指标[血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)及纤维蛋白原定量(Fib)]和血小板指标[血小板计数(PLT)、平均血小板体积(MPV)和血小板分布宽度(PDW)]检测。结果重症肝病中A组、B组和C组RBP、Fib和PLT水平低于对照组和非重症肝病组,PT、APTT、TT、MPV和PDW水平均明显高于对照组和非重症肝病组,差异均有统计学意义(P<0.05或P<0.01)。非重症肝病组RBP、Fib和PLT水平低于对照组,PT、APTT、TT、MPV水平高于对照组,差异均无统计学意义(P>0.05)。结论 RBP、凝血四项和血小板指标是重症肝病辅助诊断中的重要检测指标,临床应加强对重症肝病患者以上指标的检测。

Objective To explore the application value of serum retinol binding protein（RBP）,coagulation four indexes and platelet indexes in the auxiliary diagnosis of severe liver disease diagnosis.Methods A total of 110 outpatients and inpatients with severe liver disease in our hospital from January 2014 to December 2015,including 43 cases of acute chronic severe hepatitis（group A）,36 cases of liver cirrhosis（group B）,and 31 cases of liver cancer patients（group C）],38 cases of patients with non severe liver disease and 40 individuals undergoing the healthy physical examination person healthy were selected as the research subjects.RBP,coagulation four indexes[plasma prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）and fibrin original quantitative（Fib）]and platelet indexes[platelet count（PLT）,mean platelet volume（MPV）and platelet distribution width（PDW）]were detected in all the research subjects.Results The levels of RBP,Fib and PLT in the group A,B and C of severe liver disease were lower than those in the control group and the non-severe liver disease,while the levels of PT,APTT,TT,MPV and PDW were significantly higher than those in the control group and the non-severe liver disease group,differences were statistically significant（P〈0.05 or P〈0.01）.The levels of RBP,Fib and PLT in the non-severe liver disease group were lower than those in the control group,while the levels of PT,APTT,TT,MPV were higher than those in the control group,but the differences were not statistically significant（P〈0.05）.Conclusion RBP,coagulation four indexes and platelet indexes are the important detection indicators in the auxiliary diagnosis of severe liver disease,therefore clinic should strengthen the above indexes detections in the patients with severe liver disease.