几丁糖对干眼症患者眼表功能的影响及其疗效分析

Effect of chitosan on the ocular surface function of dry eye patients

目的：研究几丁糖（Medical Chitosan）对干眼症患者眼表功能的影响及其疗效。方法：采用随机取样法，选取2013年8月至2014年8月到我院就诊的100例（200眼）干眼症患者，并对患者的病症资料进行整理研究。然后将所选取的干眼症患者随机分为2组，每组50例（100眼）。观察组采用几丁糖联合人工泪液的方法对患者进行治疗，对照组则采用人工泪液的治疗方法。治疗后，对两组患者均进行随访1~6个月，观察并记录两组患者的眼表功能变化以及泪膜破裂时间（break-up time， BUT）、Schirmer I试验（Schirmer I test，SIT）、角膜荧光素染色（fluorescein，FL）和视功能评分等指标，最后将两组患者的治疗效果进行比较分析。结果：治疗一段时间后，两组患者BUT时间都明显增加，且观察组高于对照组，差异具有统计学意义（P〈0.05）；两组患者Schirmer I试验值都明显升高，且实验组高于对照组，差异具有显著性意义（P〈0.05）；且两组患者的角膜荧光素染色面积都明显减少，且观察组的染色面积小于对照组，同时两组患者的视功能评分都明显升高，且观察组的视功能评分高于对照组，差异具有显著统计学意义（P〈0.05）。结论：利用几丁糖治疗患者干眼症取得了良好的效果，有助于患者眼部疾病的康复，减少了患者病情加重的概率，能快速使患者恢复正常生活，减少了病患家属的心理负担，值得广泛应用。

Objective： To study the inlfuence and effect of chitosan on ocular surface function of dry eye patients.Methods： Used random sampling method to select 100 cases （200 eyes） patients with dry eye from August 2013 to August 2014 in our hospital, and conducted the research on the clinical data. hTen randomly divided the dry eye patients into two groups, each with 50 cases （100 eyes）. Observation group were treated by artiifcial tears combined chitosan, the control group were treated by artiifcial tears therapy. Atfer treatment, patients were followed up for 1 to 6 months, observed and recorded the ocular function in two groups, as well as tear iflm breakup time （BUT）, Schirmer I test （SIT）, corneal lfuorescein staining （FL） and visual function scores and other indicators, the effect of the two groups were compared and analyzed.Results： Atfer treatment, tear iflm break-up time of the two groups increasedsigniifcantly, and the observation group was higher, the difference was statistically signiifcant （P〈0.05）; Schirmer I test values of two groups are significantly higher in the observation group than that in the control group, the difference was signiifcant （P〈0.05）; and corneal lfuorescein staining area of two groups reduced signiifcantly, and the stained area of the observation group was less than that of the control group, the difference was statistically signiifcant （P〈0.05）; at the same time visual function scores were signiifcantly higher, and the visual in observation group score was higher than that in the control group, the difference was statistically significant （P〈0.05）. Conclusion： hTe use of chitosan in dry eye patients achieved good results, it contributes to the rehabilitation of patients with eye diseases, reduces the chance of sicker patients, so that patients can quickly return to normal life and reduce the psychological burden on the patient’s family, it is worthy of wider application.