摘要
在多种眼部疾病的发生发展过程中，巨噬细胞及炎性因子介导的免疫反应是重要的发病机制。在微环境信号的作用下，巨噬细胞可极化为产生不同细胞因子、受体表达、效应功能的M1、M2型巨噬细胞，巨噬细胞具有多能性和异质性，其功能和表型可以在不同的微环境信号下动态转换，从而调节免疫炎症反应。巨噬细胞极化在角膜疾病、年龄相关性黄斑变性、糖尿病视网膜病变、自身免疫性葡萄膜炎的发病机制中也起到了重要的作用，其可塑性为其成为治疗靶点提供可能。
In the development of various ocular diseases, the immune response mediated by macro- phages and inflammatory cytokine is important in the pathogenesis. Under the effect of microenvironment sig- nals, macrophages could polarize to Ml or M2 macrophages with different cytokines, receptor expression, and functions. Macrophages are versatile and heterogeneous cells that could undergo their phenotypicaUy/ functionally dynamic. Macrophage polarization was involved in the pathogenesis of the corneal disease, age- related macular degeneration, diabetic retinopathy and autoimmune uveitis, and the plasticity of macrophage make it possible to be an ideal target for therapy.
出处
《国际眼科纵览》
2016年第4期231-236,共6页
International Review of Ophthalmology
