复方斑蝥注射液对中晚期结直肠癌TGF-β1表达影响的前瞻性临床研究

Study on the Compound Cantharis Injection TGF-beta1 Expression in Patients with Locally Advanced Colorectal Cancer

目的探讨复方斑蝥注射液对中晚期结直肠癌患者TGF-β1表达的影响。方法选取潍坊市中医院肿瘤中心收治的中晚期结直肠癌患者92例,随机分为2组,每组各46例。对照组采用FOLFOX4化疗方案治疗,治疗组在化疗基础上联合复方斑蝥注射液,分别检测治疗前及治疗1、2、3个周期后两组患者血清TGF-β1水平以及评价近期临床疗效。结果在化疗进行到第1、2、3周期时,两组患者血清中TGF-β1水平均有所改善,治疗组与对照组比较水平显著降低,差异有统计学意义(P<0.05);近期临床疗效治疗组在客观反应率(ORR)和疾病控制率(DCR)上均高于对照组,但差异无统计学意义(P>0.05)。结论复方斑蝥注射液能下调结直肠癌组织中的TGF-β1的表达水平,抑制肿瘤的生长、浸润,其作用机制可能与肿瘤血管的抑制和癌细胞的死亡有关,具有良好的临床疗效。

Objective To investigate the compound cantharis injection TGF-beta1 expression in patients with locally advanced colorectal cancer. Methods Selection of locally advanced co｜orectal cancer patients admitted in Weifang hospital cancer center, 92 cases were randomly divided into 2 groups, each group of 46 cases respectively. Control group adopts FOLFOX4 chemotherapy treatment, the treatment group on the basis of chemotherapy combined compound cantharis injection, respectively to observe before treatment and after treatment 1, 2, 3, cycle two groups of patients, and serum levels of TGF-betal evaluate recent clinical curative effect. Results Two groups in chemotherapy to 1, 2, 3 cycles, two groups of TGF-betal level in serum of patients improved, the treatment group were significantly reduced compared with controls, the difference was statistically significant （P〈 0.05 ） ; Recent clinical efficacy of the treatment group in objective response rate （ORR） and disease control rates are higher than the control group （DCR）, but there was no statistically significant difference （P〉0.05）. Conclusion Compound cantharis injection could cut colorectal cancer TGF-betal expression level in the organization, and inhibit tumor growth, invasion, the action mechanism may be related to the inhibition of tumor blood vessels and the death of cancer cells, has the good clinical curative effect.