血清生物标志物在成人急性淋巴细胞白血病中表达分析

Expression analysis of serum biomarkers in adult acute lymphoblastic leukemia

目的:探讨血清生物标志物糖类抗原125(CA125)与趋化因子受体-4(CXCR4)在成人急性淋巴细胞白血病(ALL)中表达意义。方法:2010-08-2015-01住院的45例成人ALL患者作为ALL组,选择同期进行体检的健康成人45例作为对照组,2组都进行CA125与CXCR4的表达检测并进行相关性分析。结果:ALL组的CA125表达量为(75.98±10.34)U/ml,阳性表达率为86.7%(39/45),而对照组分别为(10.23±3.67)U/ml和8.9%(4/45);ALL组的CXCR4表达量为(65.33±2.34)%,阳性表达率为86.7%(41/45),而对照组分别为(20.11±4.11)%和8.9%(9/45),组间比较差异有统计学意义(P<0.05)。在ALL患者中,CA125阳性组中CXCR4阳性率为100.0%,而CA125阴性组中的CXCR4阳性率为33.3%,差异有统计学意义(P<0.05);直线分析显示CA125水平与免疫分型、临床危险度、结外病变数目、白细胞水平呈现明显相关性(P<0.05);而CXCR4也与免疫分型、临床危险度、结外病变数目、淋巴细胞水平呈现明显相关性(P<0.05)。结论:血清生物标志物CA125与CXCR4在成人ALL中都呈现高表达状况,并且可以互相影响,与临床病情存在明显相关性,可作为ALL预后判断的参考指标之一。

Objective：To investigate the expression significance of serum biomarkers CA125 and CXCR4in adult acute lymphoblastic leukemia（ALL）.Method：From August 2010 to January 2015 in our hospital,45 ALL patients were selected as the ALL group,and 45 healthy adults were selected as the control group at same period,CA125 and CXCR4expression of all the adults were detected and correlation analyzed.Result：The CA125 expression in the ALL group was（75.98 ± 10.34）U/ml and the positive rate was 86.7%（39/45）,while the control group were（10.23 ± 3.67）U/ ml and 8.9%（4/45）.The CXCR4 expression in ALL group was（65.33 ±2.34）% and the positive rate was 86.7%（41/45）,while the control group were（20.11 ± 4.11）% and 8.9%（9/45）,which the differences between the two groups were significantly（P〈0.05）.In patients with ALL with CA125 positive,the CXCR4 positive was 100.0%,while in the CA125 negative group,the CXCR4 positive rate was 33.3%,which the difference was statistically significant（P〈0.05）.Linear analysis showed that CA125 levels were correlated to the immunophenotyping,clinical risk,node number of extranodal disease and white blood cell levels（P〈0.05）;and CXCR4 was also correlated to the immunophenotyping,clinical risk,node number of extranodal disease and lymphocyte levels（P〈0.05）.Conclusion：The serum biomarker CA125 and CXCR4in adult patients with ALL showed high expression levels,and they could influence each other and have significant correlation with the clinical disease,which could be used as the one of prognosis reference indexes of ALL.