慢性阻塞性肺疾病急性加重患者呼吸道病毒的检测分析

Analysis on respiratory viruses infection status in patients with acute exacerbation of chronic obstructive pulmonary disease

目的 探讨呼吸道病毒感染与慢性阻塞性肺疾病急性加重（AECOPD）的相关性.方法 随机选择140例慢性阻塞性肺疾病急性加重（AECOPD）患者,60例健康老年志愿者为对照组,分别检测呼吸道合胞病毒（RSV）、单纯疱疹病毒（HSV）、腺病毒（ADV）、巨细胞病毒（CMV）、副流感病毒（PIV）、流感病毒A/B（FluA/B）特异性抗体IgM水平,对组间阳性率进行比较.结果 AECOPD组患者中IgM阳性率依次为RSV＞PIV＞ FluA/B＞CMV＞ADV＞ HSV.AECOPD组与对照组各病毒抗体阳性率比较差异有统计学意义（P＜0.05）.结论 病毒感染是AECOPD重要因素,病毒感染参与了AECOPD病情的进展过程,在呼吸道病毒流行的季节应做好预防工作.

Objective To investigate correlation between the respiratory virus rate and acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Methods 140 acute exacerbation （AECOPD）patients of chronic obstructive pulmonary disease were randomly selected.60 cases of healthy elderly volunteers were selected as control group.The specific antibody IgM levels of respiratory syncytial virus （RSV）,simple herpes simplex virus （HSV）,adenovirus （ADV）,cytomegalovirus （CMV）,parainfluenza virus （PIV） and influenza virus A/B （fluA/B） were detected and compared.Results The positive rates of virus were RSV 〉 PIV 〉 Flu A / B 〉 CMV 〉 ADV 〉 HSV.The positive rates of virus antibody was significantly different （P 〈 0.05） The AECOPD group and the control group.Conclusions Virus infection is an important factor in the process of AECOPD virus latent infection and repeatedly involved in AECOPD disease,respiratory virus epidemic season should do prevent work.