尼卡地平对气管插管刺激下脑电双频指数反应、收缩压和心率的影响被引量：2

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摘要目的在靶控输注丙泊酚和瑞芬太尼全身麻醉时,观察尼卡地平对气管插管刺激的脑电双频指数（BIS）反应、收缩压和心率的影响.方法择期手术患者40例,美国麻醉医师学会（ASA）分级Ⅰ或Ⅱ级,年龄18 ～ 65岁,随机分为对照组和尼卡地平组,设定丙泊酚和瑞芬太尼血浆靶控浓度分别为3.0 μg/ml和4.0 ng/ml,对照组泵入生理盐水,尼卡地平组于诱导前给予尼卡地平,以泵速每分钟3 μg/kg微量泵持续静注.观察并记录入室、插管前1分钟和插管后5分钟内的BIS、收缩压（SBP）和心率（HR）.结果两组患者插管前后的BIS水平比较,差异无统计学意义（P＞0.05）;插管前后尼卡地平组SBP均较对照组低（P＜0.05）;而插管前或后尼卡地平组HR均显著升高（P＜0.01）.插管之后,尼卡地平组的BIS变化远低于对照组（P＜0.01）;尼卡地平组的SBP变化也较对照组低（P＜0.05）;但HR变化在两组间的差异不明显（P＞0.05）.结论尼卡地平本身不影响伤害性刺激诸如气管插管前的BIS水平,但可抑制该过程中BIS增加和SBP增加,同时引起反射性心率加快.

作者吕晶

机构地区华中科技大学同济医学院附属协和医院麻醉科

出处《临床外科杂志》 2016年第8期635-637,共3页 Journal of Clinical Surgery

关键词尼卡地平气管插管脑电双频指数变化抗伤害性刺激

分类号 R614.2 [医药卫生—麻醉学]

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