醒脑静注射液联合注射用尤瑞克林治疗老年脑梗死的疗效观察

Clinical observation of Xingnaojing Injection combined with urinary kallidinogenase in treatment of senium cerebral infarction

目的研究醒脑静注射液联合注射用尤瑞克林治疗老年脑梗死的临床疗效。方法选取2012年4月—2015年4月铜川市人民医院神经内科收治的老年脑梗死患者100例,随机分为对照组和治疗组,每组各50例。对照组患者在常规治疗的同时静脉滴注注射用尤瑞克林,0.15 PNA单位,用100 m L生理盐水溶解,1次/d。治疗组在对照组治疗的基础上静脉滴注醒脑静注射液,10 m L/次加入5%葡萄糖注射液250 m L中,1次/d。两组均连续治疗15 d。观察两组的临床疗效,同时比较治疗前后两组神经功能缺损(NIHSS)评分、大脑中动脉(MCA)的峰流速(Vp)、平均流速(Vm)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为68.0%、84.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,Vp、Vm显著升高,同组治疗前后差异有统计学意义(P<0.05);治疗组这些指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论醒脑静注射液联合注射用尤瑞克林治疗老年脑梗死具有较好的临床疗效,可降低NIHSS评分,改善患者脑血流动力学,具有一定的临床推广应用价值。

Objective To investigate the efficacy of Xingnaojing Injection combined with urinary kallidinogenase in treatment of senium cerebral infarction. Methods Patients（100 cases） with senium cerebral infarction in Tongchuan People＇s Hospital from April 2013 to April 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Urinary Kallidinogenase for injection on the basis of conventional treatment, 0.15 PNA U added into normal saline 100 m L, once daily. The patients in the treatment group were iv administered with Xingnaojing Injection on the basis of the control group, 10 m L/time added into 5% glucose injection 250 m L, once daily. The patients in two groups were treated for 15 d. After treatment, the clinical efficacies were evaluated, and the change of the NIHSS scores, Vp and Vm of MCA in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 68.0% and 84.0%, respectively, and there were differences between two groups（P〈0.05）. After treatment, NIHSS scores in two groups were significantly decreased, and Vp and Vm of MCA were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, those observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Xingnaojing Injection combined with urinary kallidinogenase in treatment of senium cerebral infarction, and can reduce the NIHSS score, also can improve the cerebral blood flow dynamics, which has a certain clinical application value.