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再次遇见MET:MET 14外显子突变的“中国特色” 被引量:1

MET Met Again:“Chinese Characteristics” of MET 14 Exons Mutation
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摘要 继EGFR、ALK之后,MET驱动基因作为肺癌精准治疗的“后起之秀”走进了大众视野。然而,MET靶向治疗之路并非如EGFR或ALK一般顺利,最佳生物学标志物的寻找可谓“众里寻他千百度”。甚至,由于METLung临床试验的失败,使MET的研究一度陷入僵局。直至2014年,Camidge教授团队有关MET扩增研究的发表燃起了MET研究复兴的希望[1]。去年,关于MET 14外显子突变在肺癌中的发现再次将MET的关注度推向顶峰。
出处 《循证医学》 CSCD 2016年第4期209-210,共2页 The Journal of Evidence-Based Medicine
关键词 肺癌 精准治疗 MET 14 lung cancer accurate treatment MET 14
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参考文献7

  • 1Garber K. MET inhibitors start on road to recovery[J]. Nat Rev Drug Discov, 2014,13(8): 563-565.
  • 2Frampton GM, Ali SM,Rosenzweig M,et al. Activation of MET via diverse exon 14 splicing alterationsoccurs in multiple tumor types and confers clinical sensitivity to MET inhibitors[J]. Cancer Discov, 2015, 5(8): 850-859.
  • 3Paik PK, Drilon A, Fan PD, et al. Response to MET inhibitors in patients with stage Ⅳ lung adenocarcinomas harboring MET mutations causing exon 14 skipping[J]. Cancer Discov, 2015,5(8):842-849.
  • 4Awad MM. Impaired c-Met receptor degradation mediated by Met exon 14 mutations in non-small-cell lung cancer[J]. J Clin Oncol, 2016,34(8):879-881.
  • 5Liu SY, Mok T,Wu YL. Novel targeted agents for the treatment of lung cancer in China[J]. Cancer, 2015, 121 (Suppl 17):3089-3096.
  • 6Camidge DR, Ou SH, Shpiro G,et al. Efficacy and safety of Crizotinib in patients with advancedc-MET-amplified non-small cell lung cancer (NSCLC)[J]. J Clin Oncol (Meeting Abstracts), 2014, 32(Suppl 15): Abstr 8001.
  • 7Wu YL, Yang JCH, Kim DW, et al. Safety and efficacy of INC280 in combination with Gefitinib (gef) in patients with EGFR-mutated (mut),MET-positive NSCLC: A single-arm phase Ⅰb/Ⅱ study[J]. J Clin Oncol (Meeting Abstracts) ,2014,32(Suppl 15): Abstr 8017.

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