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益生菌调节肠道菌群,肥胖和非酒精性脂肪性肝病治疗的新希望? 被引量:6

Regulation of Gut Microbiota by Probiotics,New Hope for The Treatment of Obesity and Non-Alcoholic Fatty Liver Disease?
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摘要 肥胖是二十一世纪公共卫生面临的主要挑战之一,据WHO报道,截止到2014年,全球有19亿18岁及以上成年人超重,其中包括6亿肥胖个体。越来越多的证据表明肥胖与很多疾病,如2型糖尿病、高血压、心血管疾病等以及几种癌症的发生密切相关,尽管有许多预防和治疗肥胖的策略,但有效的手段非常有限,大多数患者难以坚持、疗效甚微,目前在世界范围内正在寻求新的方法来降低肥胖的流行和随之带来的疾病负担[1],新近研究发现,人体胃肠道微生物的组成和功能可能与肥胖的发生和发展密切相关,将非肥胖健康供体粪便转移到肥胖受体即肠道菌群移植在治疗肥胖中的作用已经得到初步证实,也有关于以抗菌药物为基础的干预措施可以减轻肥胖的个别报道,但由于治疗本身会引发新的问题,故需要进一步谨慎论证。
出处 《循证医学》 CSCD 2016年第4期212-213,共2页 The Journal of Evidence-Based Medicine
关键词 非酒精性脂肪性肝病 减肥 益生菌 肠道菌群 non-alcoholic fatty liver disease (NAFLD) weightloss prebiotic gut microbiota
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