抗结核药物的研究进展

Research Progress of the Anti-Tuberculosis Drugs

目的为进一步研发新型抗结核药物提供参考。方法通过Science Direct,Wiley,Springer Link等数据库进行文献检索,将近几年文献报道抗结核候选药物进行归纳和总结。结果最低抑菌浓度小于7μmol/L,低毒和高选择性的最有潜力的抗结核候选药物已大量出现。结论抗结核候选药物的开发思路为研发更多新型抗结核药物提供了参考。

Objective To provide a reference for further researching and developping new anti- tuberculosis drugs. Methods Through document retrieval in the databases of Science Direct, Wiley and Springer Link, etc.,the literatures about new antitubereular drugs were summarized. Results The most potent anti-tuberculosis drugs with low toxicity, a high selective index and MIC values 〈 7 μmol/L were appeared in large numbers. Conclusion The thoughts on the development of anti- tuberculosis drugs provide perspectives on the development of new anti- tuberculosis drugs.