特发性高嗜酸性粒细胞综合征累及心脏的超声心动图诊断

Cardiac involvement in idiopathic hypereosinophilic syndrome: diagnosis by echocardiography

特发性高嗜酸性粒细胞增多综合征(idiopathic hypereosinophilicsyndrome,IHES)是指无明确致病因素的血液和/或细胞中嗜酸性粒细胞持续性增多,并伴有脏器损害的一种疾病。IHES累及心脏可引起左心室收缩功能和(或)舒张功能降低、心内血栓、心肌炎、心内膜心肌纤维化、限制性心肌病、心律失常、冠状动脉病变等,致死率及致残率高。因相关症状缺乏特异性,临床易漏诊、误诊。超声心动图在IHES心脏受累的临床诊断中具有重要作用。本文就IHES伴心脏受累的病理、临床表现及超声心动图诊断进行阐释。

Idiopathic hypereosinophilic syndrome （IHES） is a disease with persistently elevated eosinophil count in peripheral blood or tissues accompanied by organ damage. The disease had no identifiable cause. Cardiac involvement is a major cause of morbid- ity and mortality. It may present as left ventricular systolic and/or diastolic dysfunction, intra-cardiac thrombus, eosinophilic myocarditis, endomyocardial fibrosis, restrictive cardiomyopathy and arrhythmia as well as coronary artery disease. The clinic features are rather diverse and nonspeeific. Eehocardiography plays an important role in diagnosis of cardiac involvement in IHES. The pathogenesis, clinic manifestation and echoeardiographie diagnosis of cardiac involvement in IHES were discussed in this review.