32例系统性红斑狼疮患者死亡原因分析

Analysis of the causes of death of 32 patients with systemic lupus erythematosus

目的分析近年来系统性红斑狼疮(systemic lupus erythematosus,SLE)住院患者的主要死亡原因。方法回顾性分析2004年1月至2015年12月四川省人民医院收治的系统性红斑狼疮死亡患者病历资料。结果 SLE住院患者2391例,死亡32例,总死亡率1.34%,最常见的死因为感染15例(46.875%),其次为本病活动11例(34.375%)。结论 SLE患者主要死因为感染,其次为本病活跃。早期诊断、及时干预及严格掌握激素及免疫抑制剂的使用,规律的随访,是改善SLE患者的预后,提高生存率的关键。

Objective To investigate the main causes of death of patients with systemic lupus erythematosus （SLE） in recent years. Methods We retrospectively investigated and analyzed the dead SLE cases after treatment in the Sichuan Provincial People＇s Hospital from January 2004 to December 2015. Results There were 32 dead cases in 2,391 hospitalized patients with SLE （ 1.34% ）. In these 32 cases,infection is the most common cause of death in SLE patients （15 cases,46. 9% ） ,and the second is the SLE itself （ 11 cases,34.4% ）. Conclusion Infection is the major cause of mortality in the SLE patients in our hospital followed by the disease activity. Early diagnosis, timely intervention, strictly mastered use of glucocorticoids and immunosuppressants as well as regular followup are significant to improve the prognosis and increase the survival rate.