舒血宁注射液联合格列齐特治疗2型糖尿病的疗效及对同型半胱氨酸和胱抑素C水平的影响

Effect and Influence of Homocysteine and Cystatin C in Type 2 Diabetes Patients treated by Shuxuening Injection Combined with Gliclazide

目的:观察舒血宁注射液联合格列齐特治疗2型糖尿病的临床疗效,及对同型半胱氨酸和胱抑素C水平的影响,探讨其作用机制。方法:2型糖尿病患者60例随机分为观察组和对照组各30例。对照组给予格列齐特降糖治疗,观察组在此基础上给加用舒血宁注射液治疗。疗程均为2周。比较两组疗效、药品不良反应,以及治疗前后患者同型半胱氨酸(Hcy)、胱抑素C(Cys C)和血糖(FBG、PBG)水平变化。结果:观察组总有效率为96.67%,明显高于对照组的63.33%(P<0.05)。治疗后,两组患者的血糖以及Hcy、Cys C水平均较治疗前明显下降(P<0.05),且观察组上述指标均低于对照组(P<0.05)。两组患者药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:舒血宁注射液对2型糖尿病患者有较好疗效,可以有效降低同型半胱氨酸和胱抑素C水平,更好的控制血糖。

Objective： To observe the effect and influence of homocysteine and cystatin C in type 2 diabetes patients treated by Shuxuening injection combined with gliclazide. Methods： Type 2 diabetic patients were randomly divided into observation group and control group,and there were 30 cases in each group. The control group was given gliclaside hypoglycemic treatment, on the basis of the observation group to combined with Shuxuening injection. The course of treatment was 2 weeks. Efficacy , adverse drug reactions , Homocysteine （ Hcy）, Cystatin C （CysC） and blood glucose （ FBG, PB） level change of two groups patients before and after treatment were compared. Results： The total effective rate of the observation group was 96.57%, which was significantly higher than that of the control group （P 〈 0.05 ）. After treatment, blood glucose and Hcy, CysC levels of the two groups of patients were significantly decreased compared with before treatment （P 〈0.05） ,and those of the observation group was much lower（P 〈0.05）. The incidence of adverse drug reactions between the two groups had no significant difference（ P 〉 0.05 ）. Conclusion： Shuxuening Injection on patients with type 2 diabetes mellitus has good curative effect, it can effectively reduce homoeysteine and cystatin C levels, better control of blood glucgse.