舒芬太尼复合丙泊酚用于儿童静脉全麻下无痛胃镜检查的麻醉效果及安全性观察

Effect and Safety of Sufentanil Combined with Propofol for Intravenous Anesthesia in Children Undergone Painless Gastroscopy

目的:观察舒芬太尼复合丙泊酚用于儿童静脉全麻下无痛胃镜检查的麻醉效果及安全性。方法:120例需进行无痛胃镜检查的患儿,通过随机数表法分为观察组(60例)和对照组(60例)。观察组使用舒芬太尼复合丙泊酚麻醉,对照组使用芬太尼复合丙泊酚麻醉。观察两组患儿在T0(麻醉前)、T1(麻醉诱导后1 min)、T2(开始检查)、T3(开始检查后2 min)、T4(结束检测)等时段血流动力学的变化,比较两组麻醉情况、住院时间、丙泊酚用量及麻醉优良率、药品不良反应。结果:在T1、T2、T3时,两组患儿平均动脉压(MAP)、心率(HR)、呼吸频率(RR)均较T0时明显下降(P<0.05);且观察组MAP、HR、RR水平均高于对照组(P<0.05)。观察组意识消失、睁眼、定向力恢复等的时间,以及出院时间均短于对照组,丙泊酚用量少于对照组(P<0.05)。观察组麻醉效果优的例数与比例均多于对照组,呼吸暂停发生率低于对照组(P<0.05)。结论:在儿童无痛胃镜检查中使用舒芬太尼复合丙泊酚进行麻醉起效快、苏醒快、手术过程中血流动力学稳定、安全性高,值得应用推广。

Objective： To investigate the effect and safety of sufentanil combined with propofol for intravenous anesthesia in children undergone painless gastroscopy. Methods： Totally 120 cases of children undergone painless gastroscopy were divided into the observation group （60 cases） and the control group （60 cases） according to the random number method. The observation group was given sufentanil combined with propofol for anesthesia, and the control group was given fentanyl and propofol for anesthesia. The hemodynamic indices at the period of T0 （ before the anesthesia）, T1 （ 1 min after the anesthesia induction）, T2 （ checking）, 33 （2min after the checking） and T4 （at the end of testing） were compared between the groups, and the anesthesia situation, hospitalization time, dosage of propofol, fine/excellent rate of anesthesia and adverse reactions were also observed. Results： In T1, T2 and T3, the MAP （ mean arterial pressure）, HR （ heart rate） and RR （ respiratory rate） were declined in the two groups when compared with those in T0 （ P 〈 0.05 ）, and those in the observation group were higher than those in the control group （P 〈 0.05 ）. The time of consciousness disappearance, eyes open, orientation force recovery and hospitalization in the observation group was shorter than that in the control group, and the propofol dosage in the observation group was lower than that in the control group（P 〈0.05） . The excellent number and rate of the observation group were better than those of the control group （P 〈 0.05 ）, and the incidence of apnea of the observation group was lower than that of the control group （P 〈 0.05）. Conchtsion： Sufentanil combined with propofol for anesthesia in children undergone painless gastroscopy has the properties of fast onset and recovery, stable hemodynamic indices during the operation and high safety, which is worthy of promoted application.