丹参多酚酸联合乌司他丁治疗急性呼吸窘迫综合征的疗效及对患者生化指标的影响

Curative Effect of Salvia Miltiorrhiza Phenolic Acid Combined with Ulinastatin on Acute Respiratory Distress Syndrome and Its Effect on Biochemical Indices of Patients

目的:探讨丹参多酚酸联合乌司他丁治疗急性呼吸窘迫综合征(ARDS)疗效及对患者生化指标的影响。方法:ARDS患者86例随机分为观察组43例与对照组43例。对照组采用乌司他丁等常规治疗,观察组在对照组基础加用丹参多酚酸注射液治疗。两组疗程均为10 d。比较两组患者治疗总有效率、治疗前后呼吸频率(RR)、心率(HR)、血气分析指标氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)、动脉血氧饱和度(Sa O2)及血浆白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平变化。结果:观察组总有效率为86.05%,明显高于对照组的67.44%(P<0.05)。治疗后,两组患者RR、HR,Pa CO2、IL-6、TNF-α、CRP等指标均有明显降低,Pa O2、Sa O2则明显增加(P<0.05),且观察组各项指标均优于对照组(P<0.05)。结论:丹参多酚酸联合乌司他丁治疗ARDS疗效显著,可明显改善患者心率、呼吸频率、血气分析及降低血清炎症因子水平,值得临床推广。

Objective： To investigate the effect of salvia miltiorrhiza phenolic acid combined with ulinastatin in the treatment of acute respiratory distress syndrome （ARDS） and the influence on the biochemical parameters of patients. Methods： Totally 86 cases of ARDS were selected and randomly divided into the observation group （43 cases） and the control group （43 eases） according to the random number table. The control group was treated with the routine treatment, and the observation group was treated with salvia mihiorrhiza phenolic and injection additionally. The treatment course was 10 days, The total effective rate, RR, and HR, PaO2, SaO2and PaCe2, IL-6, TNF-α and CRP levels and the incidence of adverse reactions were comparced between the groups.Results： The total effective rate of the observation group （86.05 % ） was higher than that of the control group （67.44%, P〈 0. 05 ）. BR and HR in the two groups were significantly decreased after the treatment （P 〈 0. 05 ）, and those in the observation group were significantly lower than those in the control group （P 〈0. 05）. After the treatment, PaO2 and SaO2 were significantly increased in the two groups, and PaCe2 was significantly decreased （P 〈 0. 05 ）, and SaO2 and PaO2 in the observation group were higher than those in the eontrol group, and PaCe2 was lower than that in the control group （P 〈 0. 05 ）. The plasma levels of IL-6, TNF-α and CRP were significantly decreased in the two groups after the treatment （ P 〈 0. 05 ）, and those in the observation group were lower than those in the control group （ P 〈 0. 05 ）. No serious adverse drug reactions were found in the two groups. Conclusion： The effect of salvia mihiorrhiza phenolic acid in the treatment of ARDS is significant, and it can significantly improve heart rate, respiratory rate, blood gas and serum inflammatory factors, which is worthy of promoted clinical application.