异甘草酸镁联合常规治疗闭合性腹外伤术后合并肝功能损害疗效观察

Clinical Efficacy of Magnesium Isoglycyrrhizinate Combined with Routine Therapy in the Treatment of Patients after Closed Abdominal Trauma Complicated with Liver Damage

目的:观察异甘草酸镁联合常规治疗对闭合性腹外伤术后合并肝功能损害患者的临床疗效及安全性。方法:闭合性腹外伤患者84例随机分为观察组与对照组,各42例。对照组采用常规治疗,观察组在对照组基础上加用异甘草酸镁治疗。两组疗程均为14 d。比较两组疗效与药品不良反应,以及治疗前后两组患者血浆白蛋白、前白蛋白,血清总胆红素(TBil)、AST、ALT水平变化。结果:观察组总有效率为90.48%,高于对照组的69.05%(P<0.05)。治疗后,两组患者血浆白蛋白、前白蛋白水平明显增加(P<0.05),血清TBil、AST、ALT水平明显下降(P<0.05);且观察组血浆白蛋白、前白蛋白水平明显高于对照组(P<0.05),血清TBil、AST、ALT水平明显低于对照组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异甘草酸镁联合常规治疗对闭合性腹外伤术后合并肝功能损害患者临床疗效显著,可明显改善患者肝功能,安全可靠。

Objective： To investigate the clinical efficacy of magnesium isoglyeyrrhizinate （MgIG） in the treatment of patients with liver damage after closed abdominal trauma. Methods： Totally 84 eases of patients with closed abdominal trauma were randomly divided into the observation group （ n = 42 ） and the control group （ n = 42 ） according to the random number table. The control group was given the conventional treatment, while the observati^m group was treated with MgIG additionally. The treatment course was lad. The clinical efficacy and the level changes of albumin, prealbumin, TBiL, AST and ALT before and after the treatment in the two groups were stud- ied and compared, and the adverse reactions during the treatment course were also compared between the groups. Results： The total effective rate of the observation group （90.48%） was significantly higher than that of the control group （ 69.05%, P 〈 0. 05 ）. After the treatment, the plasma albumin and prealbumin levels in both groups were significantly increased （ P 〈 0. 05 ）, and those in the observation group were significantly higher than those in the control group （ P 〈 0. 05 ）. The serum TBiL, AST and ALT levels in both groups were significantly decreased after the treatment （ P 〈 0. 05 ）, and those in the observation group were significantly lower than those in the control group （ P 〈 0. 05 ）. There was no serious adverse reaction during the treatment course in both groups. Conclusion： MgIG in the treatment of liver damage after closed abdominal trauma shows notable effect, which can improve liver function obviously with high safety and reliability.