蓝翘解毒口服液的质量标准的提高

Improvement of Quality Standard for Lanqiao Jiedu Oral Liquid

目的:建立并提高蓝翘解毒口服液质量标准。方法:采用TLC法对连翘、山豆根和知母进行定性鉴别,HPLC法对板蓝根进行定性鉴别,采用HPLC法测定连翘中连翘苷的含量。结果:连翘、山豆根、知母的薄层色谱斑点清晰,阴性无干扰。HPLC鉴定板蓝根的中的(R,S)-告依春,分离度良好,阴性无干扰,专属性强。连翘中连翘苷的含量测定方法专属性良好,阴性无干扰。结论:建立的质量标准专属性强,方法重复性好,可作为改进蓝翘解毒口服液的质量控制标准。

Objective ： To establish and improve the quality standard for Lanqiao Jiedu oral liquid. Methods： A TLC was used for the qualitative identification of Forsythiae Fructus, Sophorae Tonkinensis Radix Et Rhizoma and Anemarrhenae Rhizoma. An HPLC was used for the qualitative identification of Isatidis Radix. Forsythin in Forsythiae Fructus was quantitatively identified by HPLC. Results： Forsythiae Fructus, Sophorae Tonkinensis Radix Et Rhizoma and Anemarrhenae Rhizoma showed clear spots and there was no interference from the negative control. The HPLC further confirmed Isatidis Radix was （R, S）- epigoitrin. Quantitative study of forsythin revealed good specificity without interference from the negative control. Conclusion： The study provides an improved quality standard with high specificity and reproducibility, which can be applied in the quality control of Lanqiao Jiedu oral liquid.