多种试管婴儿技术与妊娠期高血压的相关性研究

Study on the relationship between multiple test tube baby technology and high blood pressure in pregnancy

目的探讨不同试管婴儿技术对妊娠期高血压疾病的影响及相关性。方法选取本院2013年6月至2015年6月收治的经试管婴儿技术受孕且终止妊娠的不孕患者600例。按照受精方式的不同分为常规体外受精-胚胎移植（in vitro fertilization,IVF）组（342例）,卵胞浆内单精子注射（intracytoplasmic sperm injection,ICSI）组（258例）,按照胚胎转移周期的不同分为新鲜周期进行胚胎移植（简称Fresh）组（407例）,冷冻周期胚胎移植（frozen-thawed embryo transfer,FT）组（193例）。分析不同组患者不孕不育的原因,并分析不同试管婴儿技术对妊娠期高血压疾病的影响。结果所有患者中,管性致不孕的患者有335例,子宫内膜异位患者有75例,排卵障碍有41例,夫精异常患者有136例,其他原因7例,不明原因6例。各组中管性因素导致不孕不育的比例最大,分别为IVF组66.7%,ICSI组41.5%,Fresh组52.1%,FT组63.7%。IVF组患者妊娠期高血压的发病率（2.3%）低于ICSI组（5.8%）,差异具有显著性（χ~2=4.8167,P=0.0282）;IVF组患者子痫前期的发病率（4.97%）低于ICSI组（5.04%）,但差异无显著性（χ~2=0.0014,P=0.9698）。Fresh组妊娠期高血压的发病率（3.93%）与FT组（3.63%）接近,差异无显著性（χ~2=0.0329,P=0.8561）;Fresh组子痫前期的发病率（4.91%）低于FT组（5.18%）,差异无显著性（χ~2=0.0197,P=0.8884）。结论 ICSI受精技术有增加妊娠期高血压疾病的风险,而胚胎进行移植前是否进行冻融与妊娠期高血压无关。

Objective To investigate the influence of different test tube baby technology on hypertensive disorder complicating pregnancy. Method Choose 2000 cases of pregnant women in our hospital from June 2013 to June 2015, a total of 600 infertile patients were screened in our hospital for pregnancy and termination of pregnancy. According to different fertilization modes people were divided to IVF group（342 cases） and ICSI group（258 cases）. According to different embryo transfer cycle people were divided to Fresh group（407 cases） and FT group（193 cases）. Analysis reasons of different groups of patients with infertility, and to analyze the effect of different test tube baby technology of hypertensive disorder complicating pregnancy. Result In all patients, tube caused by infertility patients with a total of 335 cases, endometriosis patients with a total of 75 cases, ovulation disorders a total of 41 cases, husband sperm abnormalities in patients with a total of 136 cases, other causes of a total of 7 cases, unexplained total 6 cases; in each group of factors leading to the proportion of infertility is the largest, each share of the IVF group（66.7%） respectively, ICSI group（41.5%）, fresh group（52.1%） in the FT group（63.7%）. IVF patients suffering from pregnancy hypertension ratio（2.3%） less than the ICSI group（5.8%）, the difference was statistically significant（χ~2=4.8167, P=0.0282）; IVF patients suffering from pre eclampsia ratio（4.97%） less than the ICSI group 13（5.04%）, but the difference between the contrast no statistical significance（χ~2=0.0014, P=0.9698）. Fresh group gestational period hypertension ratio（3.93%） and in the FT group（3.63%） were closed, the differences between the two groups no statistical significance（χ~2=0.0329, P=0.8561）; fresh group suffering from preeclampsia ratio（4.91%） less than the FT group（5.18%）, the difference between the two groups no significant（χ~2=0.0197, P=0.8884）. Conclusion ICSI fertilization technology has increased the risk of hypertensive disorder complicating pregnancy, and it is not related to the freezing and thawing before the embryo transfer and pregnancy induced hypertension.